RABX5_BOVIN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RABX5_BOVIN
• UniProt AC: O18973
• Protein Name: Rab5 GDP/GTP exchange factor
• Gene Name: RABGEF1
• Organism: Bos taurus (Bovine).
• Sequence Length: 492
• Subcellular Localization: Cytoplasm . Early endosome . Recycling endosome .
• Protein Description: Rab effector protein acting as linker between gamma-adaptin and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase..
• Protein Sequence: MSLKSERRGIHVDQSELLCKKGCGYYGNPAWQGFCSKCWREEYHKARQKQIQEDWELAERLQREEEEAFASSQSSQGAQSLTFSKFEEKKTNEKTRKVTTVKKFFSASSRVGAKKAEIQEAKAPSPSINRQTSIETDRVSKEFIEFLKTFHKTGQEIYKQTKLFLEAMHYKRDLSIEEQSECTQDFYQNVAERMQTRGKVPPERVEKIMDQIEKYIMTRLYKYVFCPETTDDEKKDLAIQKRIRALHWVTPQMLCVPVNEEIPEVSDMVVKAITDIIEMDSKRVPRDKLACITKCSKHIFNAIKITKNEPASADDFLPTLIYIVLKGNPPRLQSNIQYITRFCNPSRLMTGEDGYYFTNLCCAVAFIEKLDAQSLNLSQEDFDRYMSGQTSPRKQESENWSPDACLGVKQMYKNLDLLSQLNERQERIMNEAKKLEKDLIDWTDGIAKEVQDIVEKYPLEIRPPNQSVAAIDSENVENDKLPPPLQPQVYAG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
125	Phosphorylation	IQEAKAPSPSINRQT HHCCCCCCCCCCCCC	35.82	-
133	Phosphorylation	PSINRQTSIETDRVS CCCCCCCCCCHHHHH	15.30	-
152	Acetylation	EFLKTFHKTGQEIYK HHHHHHHHHHHHHHH	50.59	-
171	Acetylation	FLEAMHYKRDLSIEE HHHHHHHCCCCCHHH	25.43	-
374	Phosphorylation	IEKLDAQSLNLSQED HHHHCHHHCCCCHHH	22.42	-
378	Phosphorylation	DAQSLNLSQEDFDRY CHHHCCCCHHHHHHH	30.37	-
391	Phosphorylation	RYMSGQTSPRKQESE HHHCCCCCCCCCCCC	18.15	-
401	Phosphorylation	KQESENWSPDACLGV CCCCCCCCHHHHHHH	25.20	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RABX5_BOVIN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RABX5_BOVIN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RABX5_BOVIN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RABE1_HUMAN	RABEP1	physical	16407276
UBC_BOVIN	UBC	physical	16462746
UBC_HUMAN	UBC	physical	22705550

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.