RABF1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RABF1_ARATH
• UniProt AC: Q9CB01
• Protein Name: Ras-related protein RABF1 {ECO:0000303|PubMed:12644670}
• Gene Name: RABF1 {ECO:0000303|PubMed:12644670}
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 202
• Subcellular Localization: Early endosome membrane . Endosome membrane . Cell membrane ; Lipid-anchor . Endoplasmic reticulum .
• Protein Description: Endosomal protein probably involved in endocytosis. Probably not involved in vacuolar trafficking..
• Protein Sequence: MGCASSLPDRNSGTLSGLSNSENAVPADAKNLRVKLVLLGDSGVGKSCIVLRFVRGQFDATSKVTVGASFLSQTIALQDSTTVKFEIWDTAGQERYSALAPLYYRGAGVAVIVYDITSPESFKKAQYWVKELQKHGSPDIVMALVGNKADLHEKREVPTEDGMELAEKNGMFFIETSAKTADNINQLFEEIGKRLPRPAPSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	N-myristoyl glycine	------MGCASSLPD ------CCCCCCCCC	18.72	-
2	Myristoylation	------MGCASSLPD ------CCCCCCCCC	18.72	11532937
3	S-palmitoylation	-----MGCASSLPDR -----CCCCCCCCCC	2.99	-
3	S-palmitoylation	-----MGCASSLPDR -----CCCCCCCCCC	2.99	11532937

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RABF1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RABF1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RABF1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PLST4_ARATH	PGLCT	physical	22737156
ERDL4_ARATH	AT1G19450	physical	22737156
PLT4_ARATH	AT2G20780	physical	22737156

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Myristoylation

"Ara6, a plant-unique novel type Rab GTPase, functions in theendocytic pathway of Arabidopsis thaliana.";
Ueda T., Yamaguchi M., Uchimiya H., Nakano A.;
EMBO J. 20:4730-4741(2001).
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULARLOCATION, TISSUE SPECIFICITY, MYRISTOYLATION AT GLY-2, PALMITOYLATIONAT CYS-3, AND MUTAGENESIS OF GLY-2; CYS-3; GLN-93 AND ASN-147.
PubMed: 11532937

Palmitoylation

"Ara6, a plant-unique novel type Rab GTPase, functions in theendocytic pathway of Arabidopsis thaliana.";
Ueda T., Yamaguchi M., Uchimiya H., Nakano A.;
EMBO J. 20:4730-4741(2001).
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULARLOCATION, TISSUE SPECIFICITY, MYRISTOYLATION AT GLY-2, PALMITOYLATIONAT CYS-3, AND MUTAGENESIS OF GLY-2; CYS-3; GLN-93 AND ASN-147.
PubMed: 11532937