dbPTM

RABE2_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RABE2_RAT
UniProt AC	Q62835
Protein Name	Rab GTPase-binding effector protein 2
Gene Name	Rabep2
Organism	Rattus norvegicus (Rat).
Sequence Length	554
Subcellular Localization	Cytoplasm. Early endosome.
Protein Description	Plays a role in membrane trafficking and in homotypic early endosome fusion..
Protein Sequence	MAAAPAALALDPQPQEEQKDASESSELSRLRAELAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSYETQIAALKQERQQQQQDSEEKERELGHLKQLLARAHPLDSLEKQMEKAHEDSEKLREIVLPMEQEIAELKVKLLRAEELIQEIQRRPRQPASLHGSTELLPLSRNPSPPLEPSEEPSGDAGPAAEAFAHNCDDSASISSFSLGGAAGSVSLRGPQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDSQWEQLQVEGRQLQKELESVRRERDELQEGLSRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQRQMAELATSHKCLSQEVKRLNEENRGLRAEQLPSSALQGSEQQEDQDEALPSSIQELHQLVRHTRQQARARQQAQEHEAERLRIEIVKLREALDEETAAKASLEGQLRVQREETDVLEASLCSLRIETERVQQEHHKAQLTDLLSEQRAKALRLQAELETSEQVQRDFVRLSQALQVRLEQIRQADTLEQVRSILDEAPLRDIKDIKDS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
92	Ubiquitination	ETQIAALKQERQQQQ HHHHHHHHHHHHHHH	45.44	-
176	Phosphorylation	RRPRQPASLHGSTEL HCCCCCCCCCCCCCC	27.81	29779826
180	Phosphorylation	QPASLHGSTELLPLS CCCCCCCCCCCEECC	14.15	27097102
181	Phosphorylation	PASLHGSTELLPLSR CCCCCCCCCCEECCC	34.93	27097102
187	Phosphorylation	STELLPLSRNPSPPL CCCCEECCCCCCCCC	28.24	27097102
191	Phosphorylation	LPLSRNPSPPLEPSE EECCCCCCCCCCCCC	42.57	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RABE2_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RABE2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RABE2_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of RABE2_RAT !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RABE2_RAT

Related Literatures of Post-Translational Modification