RABE1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RABE1_RAT
• UniProt AC: O35550
• Protein Name: Rab GTPase-binding effector protein 1
• Gene Name: Rabep1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 862
• Subcellular Localization: Cytoplasm. Early endosome. Recycling endosome. Cytoplasmic vesicle.
• Protein Description: Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A..
• Protein Sequence: MAQPGPAPQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLRLEQERAQWAQYRESADREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEEDEQQRINKGKDNKKIDTEEEVKIPVVCALTQEESSTPLSNEEEHLDSTHGSVHSLDADLLLPSGDPFSKSDNDMFKEGLRRAQSTDSLGTSSSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTVSLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKEKQELEDFLRQSAEDSSHQISALVLRAQASEVLLEELQQSFSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQLAEDFILPDTVQVLRELVLKYRENIVHVRTAADHMEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKVNLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLERIRAILNDTKLTDINQLPET

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAQPGPAPQ ------CCCCCCCCC	25.03	-
107	Ubiquitination	QEAIDEVKRQWREEV HHHHHHHHHHHHHHH	36.50	-
162	Phosphorylation	ADLRRRLSEGQEEEN HHHHHHHHHCHHHHH	37.56	28432305
282	Acetylation	QLKHTWQKANDQFLE HHHHHHHHHHHHHHH	40.49	22902405
358	Phosphorylation	ALTQEESSTPLSNEE ECCCCCCCCCCCCCH	37.01	28689409
374	Phosphorylation	HLDSTHGSVHSLDAD HHHCCCCCEECCCCC	14.73	-
377	Phosphorylation	STHGSVHSLDADLLL CCCCCEECCCCCEEC	26.28	-
393	Phosphorylation	SGDPFSKSDNDMFKE CCCCCCCCCCHHHHH	40.21	22673903
407	Phosphorylation	EGLRRAQSTDSLGTS HHHHHHHCCCCCCCC	32.95	28689409
408	Phosphorylation	GLRRAQSTDSLGTSS HHHHHHCCCCCCCCH	19.96	21738781
410	Phosphorylation	RRAQSTDSLGTSSSL HHHHCCCCCCCCHHH	28.87	28689409
413	Phosphorylation	QSTDSLGTSSSLQSK HCCCCCCCCHHHHHH	30.63	21738781
414	Phosphorylation	STDSLGTSSSLQSKA CCCCCCCCHHHHHHH	19.01	27097102
415	Phosphorylation	TDSLGTSSSLQSKAL CCCCCCCHHHHHHHH	34.60	25403869
416	Phosphorylation	DSLGTSSSLQSKALG CCCCCCHHHHHHHHC	30.14	25403869
419	Phosphorylation	GTSSSLQSKALGYNY CCCHHHHHHHHCCCC	25.78	25403869
840	Phosphorylation	ERIRQADSLERIRAI HHHHHCCCHHHHHHH	34.84	25403869

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RABE1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RABE1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RABE1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of RABE1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.