RAB8B_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RAB8B_RAT
• UniProt AC: P70550
• Protein Name: Ras-related protein Rab-8B
• Gene Name: Rab8b
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 207
• Subcellular Localization: Cell membrane ; Lipid-anchor ; Cytoplasmic side . Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Recruited to phagosomes containing S.aureus or Mycobacterium (By similarity). Colocalizes with CDH1 in the basal compartment..
• Protein Description: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may be involved in polarized vesicular trafficking and neurotransmitter release. May participate in cell junction dynamics in Sertoli cells..
• Protein Sequence: MAKTYDYLFKLLLIGDSGVGKTCLLFRFSEDAFNTTFISTIGIDFKIRTIELDGKKIKLQIWDTAGQERFRTITTAYYRGAMGIMLVYDITNEKSFDNIKNWIRNIEEHASSDVERMILGNKCDMNDKRQVSKERGEKLAIDYGIKFLETSAKSSTNVEEAFFTLARDIMTKLNRKMNDSNSSGAGGPVKITESRSKKTSFFRCSLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Acetylation	-----MAKTYDYLFK -----CCCCHHHHHH	46.44	22636529
4	Phosphorylation	----MAKTYDYLFKL ----CCCCHHHHHHH	16.46	30181290
5	Phosphorylation	---MAKTYDYLFKLL ---CCCCHHHHHHHH	11.24	30181290
7	Phosphorylation	-MAKTYDYLFKLLLI -CCCCHHHHHHHHHH	12.01	30181290
58	Acetylation	ELDGKKIKLQIWDTA EECCEEEEEEEECCC	43.13	14656831
58	Ubiquitination	ELDGKKIKLQIWDTA EECCEEEEEEEECCC	43.13	-
72	Phosphorylation	AGQERFRTITTAYYR CCHHHHHHHHHHHHH	21.69	-
138	Acetylation	VSKERGEKLAIDYGI HHHHHHHHHHHHHHH	46.15	22902405
138	Ubiquitination	VSKERGEKLAIDYGI HHHHHHHHHHHHHHH	46.15	-
180	Phosphorylation	LNRKMNDSNSSGAGG HHHHHCCCCCCCCCC	33.34	27097102
182	Phosphorylation	RKMNDSNSSGAGGPV HHHCCCCCCCCCCCE	33.82	22108457
183	Phosphorylation	KMNDSNSSGAGGPVK HHCCCCCCCCCCCEE	36.59	27097102
204	Methylation	KKTSFFRCSLL---- CCCCEEEEECC----	2.58	-
204	Geranylgeranylation	KKTSFFRCSLL---- CCCCEEEEECC----	2.58	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RAB8B_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
72	T	Phosphorylation	Phosphorylation of Thr-72 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM and RAB GDP dissociation inhibitors GDI1 and GDI2.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RAB8B_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of RAB8B_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.