| UniProt ID | RAB7B_MOUSE | |
|---|---|---|
| UniProt AC | Q8VEA8 | |
| Protein Name | Ras-related protein Rab-7b | |
| Gene Name | Rab7b | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 199 | |
| Subcellular Localization |
Late endosome . Lysosome . Golgi apparatus . Golgi apparatus, trans-Golgi network . Cytoplasmic vesicle, phagosome . Cytoplasmic vesicle, phagosome membrane Lipid-anchor Cytoplasmic side . Recruited to phagosomes containing S.aureus or Mycobacter |
|
| Protein Description | Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway.. | |
| Protein Sequence | MNPRKKVDLKLIIVGALGVGKTSLLHQYVHKTFFEEYQTTLGASILSKIIILDDTTLKLQIWDTGGQERFRSMVSTFYKGSDGCILAFDVTDPESFEALDIWRDDVLAKIIPMEQSYPMVVLGNKIDLEDRKVSQEVVHGWCKEKDMPYFEVSAKNDINVVQAFEVLASRALLRYQGTAENHLIDSIKLSPGQPKSRCC | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 37 | Phosphorylation | HKTFFEEYQTTLGAS HHHHHHHHHHHHHHH | 12.17 | 29514104 | |
| 134 | Phosphorylation | DLEDRKVSQEVVHGW CCCCCCCCHHHHHHH | 24.53 | 30635358 | |
| 144 (in isoform 2) | Phosphorylation | - | 51.67 | 19144319 | |
| 149 | Phosphorylation | CKEKDMPYFEVSAKN HHCCCCCCEEEECCC | 13.01 | 30635358 | |
| 153 | Phosphorylation | DMPYFEVSAKNDINV CCCCEEEECCCCCCH | 26.74 | 30635358 | |
| 169 | Phosphorylation | QAFEVLASRALLRYQ HHHHHHHHHHHHHHC | 17.58 | - | |
| 175 | Phosphorylation | ASRALLRYQGTAENH HHHHHHHHCCCCCCC | 15.97 | 25367039 | |
| 186 | Phosphorylation | AENHLIDSIKLSPGQ CCCCEEEEEECCCCC | 18.03 | 22942356 | |
| 198 | Geranylgeranylation | PGQPKSRCC------ CCCCCCCCC------ | 4.10 | - | |
| 199 | Geranylgeranylation | GQPKSRCC------- CCCCCCCC------- | 6.41 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RAB7B_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RAB7B_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RAB7B_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of RAB7B_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-186, AND MASSSPECTROMETRY. | |
