RAB3C_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RAB3C_RAT
• UniProt AC: P62824
• Protein Name: Ras-related protein Rab-3C
• Gene Name: Rab3c
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 227
• Subcellular Localization: Cell membrane ; Lipid-anchor ; Cytoplasmic side .
• Protein Description: Protein transport. Probably involved in vesicular traffic (By similarity)..
• Protein Sequence: MRHEAPMQMASAQDARFGQKDSSDQNFDYMFKLLIIGNSSVGKTSFLFRYADDSFTSAFVSTVGIDFKVKTVFKNEKRIKLQIWDTAGQERYRTITTAYYRGAMGFILMYDITNEESFNAVQDWSTQIKTYSWDNAQVILAGNKCDMEDERVVSTERGQRLGEQLGFEFFETSAKDNINVKQTFERLVDIICDKMSESLETDPAITAAKQSTRLKETPPPPQPNCGC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
74	Acetylation	FKVKTVFKNEKRIKL EEEEEEEECCEEEEE	60.92	22902405
80	Acetylation	FKNEKRIKLQIWDTA EECCEEEEEEEEECC	38.07	14656791
80	Ubiquitination	FKNEKRIKLQIWDTA EECCEEEEEEEEECC	38.07	-
86	Phosphorylation	IKLQIWDTAGQERYR EEEEEEECCCHHHHH	20.07	-
181	Acetylation	AKDNINVKQTFERLV CCCCCCHHHHHHHHH	38.85	22902405
181	Ubiquitination	AKDNINVKQTFERLV CCCCCCHHHHHHHHH	38.85	-
196	Phosphorylation	DIICDKMSESLETDP HHHHHHCCHHCCCCH	29.76	-
198	Phosphorylation	ICDKMSESLETDPAI HHHHCCHHCCCCHHH	24.97	28432305
206	Phosphorylation	LETDPAITAAKQSTR CCCCHHHHHHHHHCC	23.75	-
209	Ubiquitination	DPAITAAKQSTRLKE CHHHHHHHHHCCCCC	42.17	-
211	Phosphorylation	AITAAKQSTRLKETP HHHHHHHHCCCCCCC	18.13	25403869
212	Phosphorylation	ITAAKQSTRLKETPP HHHHHHHCCCCCCCC	37.21	25403869
225	Geranylgeranylation	PPPPQPNCGC----- CCCCCCCCCC-----	8.19	-
227	Methylation	PPQPNCGC------- CCCCCCCC-------	5.70	-
227	Geranylgeranylation	PPQPNCGC------- CCCCCCCC-------	5.70	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RAB3C_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
86	T	Phosphorylation	Phosphorylation of Thr-86 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM and RAB GDP dissociation inhibitor GDI2.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RAB3C_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of RAB3C_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.