RAB3A_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RAB3A_RAT
• UniProt AC: P63012
• Protein Name: Ras-related protein Rab-3A
• Gene Name: Rab3a
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 220
• Subcellular Localization: Cell membrane ; Lipid-anchor ; Cytoplasmic side .
• Protein Description: Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (By similarity)..
• Protein Sequence: MASATDSRYGQKESSDQNFDYMFKILIIGNSSVGKTSFLFRYADDSFTPAFVSTVGIDFKVKTIYRNDKRIKLQIWDTAGQERYRTITTAYYRGAMGFILMYDITNEESFNAVQDWSTQIKTYSWDNAQVLLVGNKCDMEDERVVSSERGRQLADHLGFEFFEASAKDNINVKQTFERLVDVICEKMSESLDTADPAVTGAKQGPQLTDQQAPPHQDCAC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MASATDSRYGQKES -CCCCCCCCCCCCCC	24.05	23984901
14	Phosphorylation	SRYGQKESSDQNFDY CCCCCCCCCCCCCCE	46.37	28432305
15	Phosphorylation	RYGQKESSDQNFDYM CCCCCCCCCCCCCEE	44.28	28432305
72	Acetylation	YRNDKRIKLQIWDTA EECCCEEEEEEECCC	38.07	14656801
72	Ubiquitination	YRNDKRIKLQIWDTA EECCCEEEEEEECCC	38.07	-
86	Phosphorylation	AGQERYRTITTAYYR CCHHHHHHHHHHHHH	17.46	-
173	Acetylation	AKDNINVKQTFERLV HCCCCCHHHHHHHHH	38.85	14507323
173	Ubiquitination	AKDNINVKQTFERLV HCCCCCHHHHHHHHH	38.85	-
188	Phosphorylation	DVICEKMSESLDTAD HHHHHHHHHCCCCCC	34.79	25403869
190	Phosphorylation	ICEKMSESLDTADPA HHHHHHHCCCCCCCC	25.00	30240740
218	Geranylgeranylation	QAPPHQDCAC----- CCCCCCCCCC-----	3.15	-
220	Methylation	PPHQDCAC------- CCCCCCCC-------	7.82	-
220	Geranylgeranylation	PPHQDCAC------- CCCCCCCC-------	7.82	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RAB3A_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
86	T	Phosphorylation	Phosphorylation of Thr-86 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM and RAB GDP dissociation inhibitors GDI1 and GDI2.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RAB3A_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of RAB3A_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.