RAB26_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RAB26_MOUSE
• UniProt AC: Q504M8
• Protein Name: Ras-related protein Rab-26
• Gene Name: Rab26
• Organism: Mus musculus (Mouse).
• Sequence Length: 260
• Subcellular Localization: Cytoplasmic vesicle, secretory vesicle membrane ; Lipid-anchor ; Cytoplasmic side . Golgi apparatus membrane ; Lipid-anchor ; Cytoplasmic side . Not localized at the plasma membrane (By similarity). Inhibition of S-geranylgeranyl cysteine formation a
• Protein Description: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Mediates transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. Plays a role in the maturation of zymogenic granules and in pepsinogen secretion in the stomach (By similarity). Plays a role in the secretion of amylase from acinar granules in the parotid gland..
• Protein Sequence: MSRKKTPKSKGGSEPATSTLPAAAAATNGPRLAHPRTVRPGPEAPPNGPPQSIRPSLGSTGDFYDVAFKVMLVGDSGVGKTCLLVRFKDGAFLAGTFISTVGIDFRNKVLDVDGMKVKLQIWDTAGQERFRSVTHAYYRDAHALLLLYDITNKDSFDNIQAWLTEIQEYAQQDVVLMLLGNKVDSTQDRVVKREDGEKLAKEYGLPFMETSARTGLNVDLAFTAIAKELKQRSAKAPSEPRFRLHDYVKREGRGVSCCRL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
59	Phosphorylation	SIRPSLGSTGDFYDV CCCCCCCCCCCHHHE	34.21	21082442
238	Phosphorylation	QRSAKAPSEPRFRLH HHHCCCCCCCCCHHH	66.16	24719451
257	Geranylgeranylation	REGRGVSCCRL---- HCCCCCCCCCC----	1.13	-
258	Geranylgeranylation	EGRGVSCCRL----- CCCCCCCCCC-----	3.75	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RAB26_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RAB26_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RAB26_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of RAB26_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.