RAB17_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RAB17_MOUSE
• UniProt AC: P35292
• Protein Name: Ras-related protein Rab-17
• Gene Name: Rab17
• Organism: Mus musculus (Mouse).
• Sequence Length: 214
• Subcellular Localization: Recycling endosome membrane ; Lipid-anchor ; Cytoplasmic side . Melanosome . Cell projection, dendrite . According to a report the protein is localized at the basolateral and apical plasma membrane of kidney epithelial cells (PubMed:8486736). It was
• Protein Description: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in transcytosis, the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. Mainly observed in epithelial cells, transcytosis mediates for instance, the transcellular transport of immunoglobulins from the basolateral surface to the apical surface. Most probably controls membrane trafficking through apical recycling endosomes in a post-endocytic step of transcytosis. Required for melanosome transport and release from melanocytes, it also regulates dendrite and dendritic spine development. May also play a role in cell migration..
• Protein Sequence: MAQAAGLPQASTASGQPYVSKLVLLGSSSVGKTSLALRYMKQDFSNVLPTVGCAFFTKVLDLGSSSLKLEIWDTAGQEKYQSVCHLYFRGANAALLVYDITRKDSFHKAQQWLEDLEKEFQPGEVVVMLVGNKTDLGEEREVTFQEGKEFAESKSLLFMETSAKLNYQVSEIFNTVAQELLQRAGDTGSSRPQEGEAVALNQEPPIRQRQCCAR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	Phosphorylation	SKLVLLGSSSVGKTS EEEEEECCCCCCHHH	21.29	29899451
28	Phosphorylation	KLVLLGSSSVGKTSL EEEEECCCCCCHHHH	27.52	29472430
29	Phosphorylation	LVLLGSSSVGKTSLA EEEECCCCCCHHHHH	36.26	26239621
211	Geranylgeranylation	PPIRQRQCCAR---- CCCCCHHHCCC----	1.82	9624171
211	Geranylgeranylation	PPIRQRQCCAR---- CCCCCHHHCCC----	1.82	9624171
212	Geranylgeranylation	PIRQRQCCAR----- CCCCHHHCCC-----	2.43	9624171
212	Geranylgeranylation	PIRQRQCCAR----- CCCCHHHCCC-----	2.43	9624171

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RAB17_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RAB17_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RAB17_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of RAB17_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.