R51A1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: R51A1_MOUSE
• UniProt AC: Q8C551
• Protein Name: RAD51-associated protein 1
• Gene Name: Rad51ap1 {ECO:0000312|MGI:MGI:1098224}
• Organism: Mus musculus (Mouse).
• Sequence Length: 337
• Subcellular Localization: Nucleus . Colocalizes with RAD51 to multiple nuclear foci.
• Protein Description: May participate in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Functionally cooperates with PALB2 in promoting of D-loop formation by RAD51. Binds to single and double stranded DNA, and is capable of aggregating DNA. Also binds RNA (By similarity)..
• Protein Sequence: MVRPTRNRKPINYSQFEDSGNDSDDDFISSSTPVNKSKTVPKVLKQDKPKPNLKNLQKEEVLPTEPPKKRVALDDKVFQRGLEVALALSVKELPTLTNQVKKSKEKSTDKQGKEKTENTGKPPRVSNCSVASDDVEDLDKITEEGDASSVEGERKSPSQAKAPRRRAPSEGSDGSSANDTESESATGEGSESDPDFDESKESDEDFGVRRSKESKKKTVQKKPAGEKKERKSKPKCEASVTSVDPAPAAIKSGSPSLPQAVGLPSEATRKPAIMCSPSAESKRPKWVPPAASGSRNSSSNALAGTPAKSPSQSLRLGLSRLAPVKRLHPSATSSQVR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	RNRKPINYSQFEDSG CCCCCCCHHHHCCCC	12.45	25619855
14	Phosphorylation	NRKPINYSQFEDSGN CCCCCCHHHHCCCCC	24.73	25619855
19	Phosphorylation	NYSQFEDSGNDSDDD CHHHHCCCCCCCCCC	32.09	26824392
23	Phosphorylation	FEDSGNDSDDDFISS HCCCCCCCCCCCHHC	47.11	26824392
29	Phosphorylation	DSDDDFISSSTPVNK CCCCCCHHCCCCCCC	20.45	25619855
30	Phosphorylation	SDDDFISSSTPVNKS CCCCCHHCCCCCCCC	33.15	25619855
31	Phosphorylation	DDDFISSSTPVNKSK CCCCHHCCCCCCCCC	29.91	25619855
32	Phosphorylation	DDFISSSTPVNKSKT CCCHHCCCCCCCCCC	32.95	25619855
37	Phosphorylation	SSTPVNKSKTVPKVL CCCCCCCCCCCCHHH	28.49	29472430
39	Phosphorylation	TPVNKSKTVPKVLKQ CCCCCCCCCCHHHHC	49.48	29472430
103	Phosphorylation	LTNQVKKSKEKSTDK HHHHHHHHHHCCCCC	40.09	-
104	Acetylation	TNQVKKSKEKSTDKQ HHHHHHHHHCCCCCC	77.40	19859203
107	Phosphorylation	VKKSKEKSTDKQGKE HHHHHHCCCCCCCHH	42.82	-
113	Acetylation	KSTDKQGKEKTENTG CCCCCCCHHHHCCCC	54.25	19859209
115	Acetylation	TDKQGKEKTENTGKP CCCCCHHHHCCCCCC	65.70	19859215
132	Phosphorylation	VSNCSVASDDVEDLD CCCCCCCCCCHHHHH	31.99	25338131
148	Phosphorylation	ITEEGDASSVEGERK HCCCCCCCCCCCCCC	39.39	27087446
149	Phosphorylation	TEEGDASSVEGERKS CCCCCCCCCCCCCCC	26.38	27087446
156	Phosphorylation	SVEGERKSPSQAKAP CCCCCCCCHHHCCCC	35.68	26643407
158	Phosphorylation	EGERKSPSQAKAPRR CCCCCCHHHCCCCCC	50.27	26643407
169	Phosphorylation	APRRRAPSEGSDGSS CCCCCCCCCCCCCCC	54.31	25293948
172	Phosphorylation	RRAPSEGSDGSSAND CCCCCCCCCCCCCCC	34.44	25293948
175	Phosphorylation	PSEGSDGSSANDTES CCCCCCCCCCCCCCC	31.13	25293948
176	Phosphorylation	SEGSDGSSANDTESE CCCCCCCCCCCCCCC	36.30	25293948
180	Phosphorylation	DGSSANDTESESATG CCCCCCCCCCCCCCC	41.01	25293948
182	Phosphorylation	SSANDTESESATGEG CCCCCCCCCCCCCCC	38.66	25293948
184	Phosphorylation	ANDTESESATGEGSE CCCCCCCCCCCCCCC	40.17	25293948
202	Phosphorylation	DFDESKESDEDFGVR CCCHHHHCCCCCCCC	50.46	28973931
217	Acetylation	RSKESKKKTVQKKPA CCHHHHCCCCCCCCC	58.63	22902405
221	Acetylation	SKKKTVQKKPAGEKK HHCCCCCCCCCCCCC	57.28	22902405
252	Phosphorylation	PAPAAIKSGSPSLPQ CCCHHHHCCCCCCCH	38.09	28725479
254	Phosphorylation	PAAIKSGSPSLPQAV CHHHHCCCCCCCHHH	20.57	22942356
256	Phosphorylation	AIKSGSPSLPQAVGL HHHCCCCCCCHHHCC	55.14	25619855
265	Phosphorylation	PQAVGLPSEATRKPA CHHHCCCCHHCCCCC	44.93	26643407
268	Phosphorylation	VGLPSEATRKPAIMC HCCCCHHCCCCCEEE	34.86	26643407
275	Glutathionylation	TRKPAIMCSPSAESK CCCCCEEECCCCCCC	4.41	24333276
276	Phosphorylation	RKPAIMCSPSAESKR CCCCEEECCCCCCCC	12.43	25619855
278	Phosphorylation	PAIMCSPSAESKRPK CCEEECCCCCCCCCC	28.51	25619855
281	Phosphorylation	MCSPSAESKRPKWVP EECCCCCCCCCCCCC	33.41	28066266
292	Phosphorylation	KWVPPAASGSRNSSS CCCCCCCCCCCCCCC	39.13	22871156
294	Phosphorylation	VPPAASGSRNSSSNA CCCCCCCCCCCCCCC	26.29	22871156
305	Phosphorylation	SSNALAGTPAKSPSQ CCCCCCCCCCCCHHH	17.92	25619855
309	Phosphorylation	LAGTPAKSPSQSLRL CCCCCCCCHHHHHHH	31.71	25619855
311	Phosphorylation	GTPAKSPSQSLRLGL CCCCCCHHHHHHHCH	39.22	25619855
313	Phosphorylation	PAKSPSQSLRLGLSR CCCCHHHHHHHCHHH	21.57	28066266

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of R51A1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of R51A1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of R51A1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of R51A1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.