QCR6_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: QCR6_MOUSE
• UniProt AC: P99028
• Protein Name: Cytochrome b-c1 complex subunit 6, mitochondrial
• Gene Name: Uqcrh
• Organism: Mus musculus (Mouse).
• Sequence Length: 89
• Subcellular Localization: Mitochondrion inner membrane .
• Protein Description: This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1 (By similarity)..
• Protein Sequence: MGLEDERKMLTGSGDPKEEEEEELVDPLTTVREHCEQLEKCVKARERLELCDNRVSSRSQTEEDCTEELFDFLHARDHCVAHKLFKNLK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	EDERKMLTGSGDPKE HHHHHHHCCCCCCHH	26.29	22817900
13	Phosphorylation	ERKMLTGSGDPKEEE HHHHHCCCCCCHHHH	34.48	22817900
29	Phosphorylation	EELVDPLTTVREHCE HHHCCHHHHHHHHHH	28.74	-
30	Phosphorylation	ELVDPLTTVREHCEQ HHCCHHHHHHHHHHH	25.83	-
35	S-nitrosocysteine	LTTVREHCEQLEKCV HHHHHHHHHHHHHHH	2.82	-
35	S-nitrosylation	LTTVREHCEQLEKCV HHHHHHHHHHHHHHH	2.82	21278135
40	Acetylation	EHCEQLEKCVKARER HHHHHHHHHHHHHHH	53.58	23576753
40	Malonylation	EHCEQLEKCVKARER HHHHHHHHHHHHHHH	53.58	26320211
51	S-palmitoylation	ARERLELCDNRVSSR HHHHHHHCCCCCCCC	2.96	26165157
51	S-nitrosylation	ARERLELCDNRVSSR HHHHHHHCCCCCCCC	2.96	21278135
51	Glutathionylation	ARERLELCDNRVSSR HHHHHHHCCCCCCCC	2.96	24333276
51	S-nitrosocysteine	ARERLELCDNRVSSR HHHHHHHCCCCCCCC	2.96	-
56	Phosphorylation	ELCDNRVSSRSQTEE HHCCCCCCCCCCCHH	19.45	26643407
57	Phosphorylation	LCDNRVSSRSQTEED HCCCCCCCCCCCHHH	32.85	26643407
59	Phosphorylation	DNRVSSRSQTEEDCT CCCCCCCCCCHHHHH	43.32	21082442
61	Phosphorylation	RVSSRSQTEEDCTEE CCCCCCCCHHHHHHH	42.46	21082442
65	S-nitrosocysteine	RSQTEEDCTEELFDF CCCCHHHHHHHHHHH	6.12	-
65	Glutathionylation	RSQTEEDCTEELFDF CCCCHHHHHHHHHHH	6.12	24333276
65	S-nitrosylation	RSQTEEDCTEELFDF CCCCHHHHHHHHHHH	6.12	24895380
66	Phosphorylation	SQTEEDCTEELFDFL CCCHHHHHHHHHHHH	44.83	23140645
83	Acetylation	RDHCVAHKLFKNLK- HHHHHHHHHHHHCC-	45.97	23576753
83	Phosphoglycerylation	RDHCVAHKLFKNLK- HHHHHHHHHHHHCC-	45.97	-
83	Malonylation	RDHCVAHKLFKNLK- HHHHHHHHHHHHCC-	45.97	26320211
83	Succinylation	RDHCVAHKLFKNLK- HHHHHHHHHHHHCC-	45.97	24315375
86	Acetylation	CVAHKLFKNLK---- HHHHHHHHHCC----	72.33	23864654
86	Ubiquitination	CVAHKLFKNLK---- HHHHHHHHHCC----	72.33	27667366
86	Malonylation	CVAHKLFKNLK---- HHHHHHHHHCC----	72.33	26073543

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of QCR6_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of QCR6_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of QCR6_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of QCR6_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Substrate and functional diversity of lysine acetylation revealed bya proteomics survey.";
Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T.,Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.-J., Zhao Y.;
Mol. Cell 23:607-618(2006).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-40, AND MASS SPECTROMETRY.
PubMed: 16916647

Phosphorylation

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-61, AND MASSSPECTROMETRY.
PubMed: 17242355