QCR2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: QCR2_RAT
• UniProt AC: P32551
• Protein Name: Cytochrome b-c1 complex subunit 2, mitochondrial
• Gene Name: Uqcrc2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 452
• Subcellular Localization: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
• Protein Description: This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. The core protein 2 is required for the assembly of the complex..
• Protein Sequence: MKLLSRAGSFSRFYSLKVAPKLKTSAPGGVPLQPQELEFTKLPNGLVIASLENYAPLSRIGLFIKAGSRYENYNYLGTSHLLRLASTLTTKGASSFKITRGIEAVGGKLSVTATRENMAYTVEGIRDDIEILMEFLLNVTTAPEFRRWEVAALRSQLKIDKAVAFQNPQTRIIENLHDVAYKNALANPLYCPDYRMGKITSEELHYFVQNHFTSARMALVGLGVSHSILKEVAEQFLNIRGGLGLAGAKAKYRGGEIREQNGDNLVHAAIVAESAAIGNAEANAFSVLQHLLGAGPHIKRGNNTTSLLSQSVAKGSQQPFDVSAFNASYSDSGLFGIYTVSQAAAAGDVINAAYNQVKAVAQGNLSSADVQAAKNKLKAGYLMSVETSEGFLSEIGSQALATGSYMPPPTVLQQIDAVADADVVKAAKKFVSGKKSMTASGNLGHTPFLDEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	KLLSRAGSFSRFYSL CCHHCCCCCHHEEEE	21.04	22673903
11	Phosphorylation	LSRAGSFSRFYSLKV HHCCCCCHHEEEEEE	24.15	22673903
23	Acetylation	LKVAPKLKTSAPGGV EEECCCCCCCCCCCC	46.70	26302492
24	Phosphorylation	KVAPKLKTSAPGGVP EECCCCCCCCCCCCC	40.32	23991683
25	Phosphorylation	VAPKLKTSAPGGVPL ECCCCCCCCCCCCCC	30.77	23991683
41	Acetylation	PQELEFTKLPNGLVI CCEEEEEECCCCEEE	68.23	26302492
54	Phosphorylation	VIASLENYAPLSRIG EEEEECCCCCHHHEE	10.54	28689409
65	Acetylation	SRIGLFIKAGSRYEN HHEEEEEECCCCCCC	39.08	22902405
70	Phosphorylation	FIKAGSRYENYNYLG EEECCCCCCCCCCCC	15.38	23991683
73	Phosphorylation	AGSRYENYNYLGTSH CCCCCCCCCCCCHHH	8.01	23991683
75	Phosphorylation	SRYENYNYLGTSHLL CCCCCCCCCCHHHHH	8.99	23991683
91	Acetylation	LASTLTTKGASSFKI HHHHHCCCCCCCCEE	47.44	22902405
97	Acetylation	TKGASSFKITRGIEA CCCCCCCEEEECEEE	45.15	22902405
112	Phosphorylation	VGGKLSVTATRENMA ECCEEEEEEEECCCC	20.95	23991683
114	Phosphorylation	GKLSVTATRENMAYT CEEEEEEEECCCCEE	29.20	23991683
155	Phosphorylation	WEVAALRSQLKIDKA HHHHHHHHHHCCCCH	40.49	23991683
158	Acetylation	AALRSQLKIDKAVAF HHHHHHHCCCCHHHC	41.02	22902405
161	Acetylation	RSQLKIDKAVAFQNP HHHHCCCCHHHCCCC	48.51	22902405
194	Phosphorylation	NPLYCPDYRMGKITS CCCCCCCCCCCCCCH	6.40	-
198	Acetylation	CPDYRMGKITSEELH CCCCCCCCCCHHHHH	33.21	22902405
200	Phosphorylation	DYRMGKITSEELHYF CCCCCCCCHHHHHHH	33.30	23991683
201	Phosphorylation	YRMGKITSEELHYFV CCCCCCCHHHHHHHH	32.33	28689409
206	Phosphorylation	ITSEELHYFVQNHFT CCHHHHHHHHHHCCH	20.33	23991683
213	Phosphorylation	YFVQNHFTSARMALV HHHHHCCHHHHHHHH	17.58	23991683
214	Phosphorylation	FVQNHFTSARMALVG HHHHCCHHHHHHHHH	16.97	23991683
225	O-linked_Glycosylation	ALVGLGVSHSILKEV HHHHHCCCHHHHHHH	15.09	27213235
227	Phosphorylation	VGLGVSHSILKEVAE HHHCCCHHHHHHHHH	23.31	23991683
249	Acetylation	GLGLAGAKAKYRGGE CCCCCCCCCHHCCCC	44.48	13578625
251	Acetylation	GLAGAKAKYRGGEIR CCCCCCCHHCCCCCC	34.47	22902405
366	Phosphorylation	AVAQGNLSSADVQAA HHHCCCCCHHHHHHH	27.72	23991683
367	Phosphorylation	VAQGNLSSADVQAAK HHCCCCCHHHHHHHH	31.49	23991683
429	Acetylation	DVVKAAKKFVSGKKS HHHHHHHHHHCCCCC	46.39	22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of QCR2_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of QCR2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of QCR2_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of QCR2_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.