| UniProt ID | PYY_HUMAN | |
|---|---|---|
| UniProt AC | P10082 | |
| Protein Name | Peptide YY {ECO:0000303|PubMed:2587421} | |
| Gene Name | PYY | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 97 | |
| Subcellular Localization | Secreted. | |
| Protein Description | This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility.. | |
| Protein Sequence | MVFVRRPWPALTTVLLALLVCLGALVDAYPIKPEAPREDASPEELNRYYASLRHYLNLVTRQRYGKRDGPDTLLSKTFFPDGEDRPVRSRSEGPDLW | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 41 | Phosphorylation | EAPREDASPEELNRY CCCCCCCCHHHHHHH | 45.20 | 24043423 | |
| 48 | Phosphorylation | SPEELNRYYASLRHY CHHHHHHHHHHHHHH | 11.43 | 24043423 | |
| 49 | Phosphorylation | PEELNRYYASLRHYL HHHHHHHHHHHHHHH | 6.10 | 24043423 | |
| 51 | Phosphorylation | ELNRYYASLRHYLNL HHHHHHHHHHHHHHH | 15.15 | 24043423 | |
| 55 | Phosphorylation | YYASLRHYLNLVTRQ HHHHHHHHHHHHHHH | 7.28 | 24043423 | |
| 60 | Phosphorylation | RHYLNLVTRQRYGKR HHHHHHHHHHHHCCC | 25.01 | 24043423 | |
| 64 | Tyrosine amide | NLVTRQRYGKRDGPD HHHHHHHHCCCCCCC | 20.75 | - | |
| 64 | Amidation | NLVTRQRYGKRDGPD HHHHHHHHCCCCCCC | 20.75 | 2587421 | |
| 75 | Phosphorylation | DGPDTLLSKTFFPDG CCCCCCHHCCCCCCC | 32.53 | 24719451 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PYY_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PYY_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PYY_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of PYY_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Amidation | |
| Reference | PubMed |
| "A new molecular form of PYY: structural characterization of humanPYY(3-36) and PYY(1-36)."; Eberlein G.A., Eysselein V.E., Schaeffer M., Layer P., Grandt D.,Goebell H., Niebel W., Davis M., Lee T.D., Shively J.E.,Reeve J.R. Jr.; Peptides 10:797-803(1989). Cited for: PROTEIN SEQUENCE OF 29-64, AMIDATION AT TYR-64, AND VARIANT GLY-37. | |
| "Isolation and primary structure of human peptide YY."; Tatemoto K., Nakano I., Makk G., Angwin P., Mann M., Schilling J.,Go V.L.W.; Biochem. Biophys. Res. Commun. 157:713-717(1988). Cited for: PROTEIN SEQUENCE OF 29-64, AMIDATION AT TYR-64, SYNTHESIS OF 29-64,AND VARIANT GLY-37. | |
