PYGB_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PYGB_RAT
• UniProt AC: P53534
• Protein Name: Glycogen phosphorylase, brain form
• Gene Name: Pygb
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 838
• Protein Description: Glycogen phosphorylase that regulates glycogen mobilization (By similarity). Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties..
• Protein Sequence: MAKPLTDSERQKQISVRGIAGLGDVAEVRKSFNRHLHFTLVKDRNVATPRDYFFALAHTVRDHLVGRWIRTQQHYYERDPKRIYYLSLEFYMGRTLQNTMVNLGLQTACDEATYQLGLDLEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKIVNGWQVEEADDWLRYGNPWEKARPEYMLPVHFYGRVEHTPNGVLWLDTQVVLAMPYDTPVPGYKNNTVNTMRLWSAKAPNDFKLKDFNVGDYIEAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKSSKFGCRDPVRTCFETFPDKVAIQLNDTHPALSIPELMRILVDVEKVDWDKAWEITKKTCAYTNHTVLPEALERWPVSMFEKLLPRHLEIIYAINQRHLDHVAALFPGDVDRLRRMSVIEEGDCKRINMAHLCVIGSHAVNGVARIHSEIVKQSVFKDFYELEPEKFQNKTNGITPRRWLLLCNPGLAEIIVERIGEGFLTDLSQLKKLLSLVDDEAFIRDVAKVKQENKLKFSAQLEKEYKVKINPCSMFDVHVKRIHEYKRQLLNCLHIITLYNRIKKDPTKTFVPRTVMIGGKAAPGYHMAKMIIKLVTSIGDVVNHDPVVGDRLRVIFLENYRVSLAEKVIPAADLSQQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENLFIFGMRVEDVEALDQKGYNAQEFYERLPELRQAVDQISSGFFSPKDPDCFKDVVNMLMYHDRFKVFADYEAYIQCQAQVDHLYRNPKDWTKKVIRNIACSGKFSSDRTITEYAREIWGVEPSDLQIPPP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAKPLTDSE ------CCCCCCHHH	23.36	-
3	Ubiquitination	-----MAKPLTDSER -----CCCCCCHHHH	38.98	-
3	Acetylation	-----MAKPLTDSER -----CCCCCCHHHH	38.98	22902405
15	Phosphorylation	SERQKQISVRGIAGL HHHHHHHHHHCCCCC	11.85	28826663
186	Phosphorylation	EADDWLRYGNPWEKA ECCCHHHCCCHHHHC	21.05	22673903
197	Phosphorylation	WEKARPEYMLPVHFY HHHCCCCCEEEEEEE	13.46	-
204	Phosphorylation	YMLPVHFYGRVEHTP CEEEEEEEECCEECC	6.80	-
227	Phosphorylation	QVVLAMPYDTPVPGY EEEEECCCCCCCCCC	21.26	22673903
254	Acetylation	AKAPNDFKLKDFNVG CCCCCCCCCCCCCHH	58.45	22902405
256	Acetylation	APNDFKLKDFNVGDY CCCCCCCCCCCHHHH	61.95	22902405
364	Acetylation	VEKVDWDKAWEITKK HHHCCHHHHHHHHHH	51.66	22902405
370	Acetylation	DKAWEITKKTCAYTN HHHHHHHHHHHCCCC	52.31	22902405
391	Phosphorylation	ALERWPVSMFEKLLP HHHHCCHHHHHHHHH	17.42	22673903
430	Phosphorylation	VDRLRRMSVIEEGDC HHHHHHCCEECCCCC	20.38	23984901
473	Phosphorylation	QSVFKDFYELEPEKF HHHCCCHHHCCHHHH	29.73	-
483	Ubiquitination	EPEKFQNKTNGITPR CHHHHCCCCCCCCHH	32.36	-
520	Acetylation	LTDLSQLKKLLSLVD CCCHHHHHHHHHHCC	33.47	22902405
521	Ubiquitination	TDLSQLKKLLSLVDD CCHHHHHHHHHHCCH	64.35	-
524	Phosphorylation	SQLKKLLSLVDDEAF HHHHHHHHHCCHHHH	36.46	22108457
552	Acetylation	KFSAQLEKEYKVKIN CEEECCCHHHCCCCC	74.96	22902405
681	Other	ASGTGNMKFMLNGAL CCCCCCCEEEECCEE	31.46	-
681	N6-(pyridoxal phosphate)lysine	ASGTGNMKFMLNGAL CCCCCCCEEEECCEE	31.46	-
752	Phosphorylation	QISSGFFSPKDPDCF HHHCCCCCCCCCCHH	28.87	25575281

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
15	S	Phosphorylation	Kinase	PHK-FAMILY	-	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
15	S	Phosphorylation	Phosphorylation of Ser-15 converts phosphorylase B (unphosphorylated) to phosphorylase A.	22673903

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PYGB_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of PYGB_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.