PYC_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PYC_SCHPO
• UniProt AC: Q9UUE1
• Protein Name: Pyruvate carboxylase
• Gene Name: pyr1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 1185
• Subcellular Localization: Cytoplasm.
• Protein Description: Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second..
• Protein Sequence: MTSKYDALLHNQSTNTNPFSKLQDRSSLLGEKFTKVLVANRSEIAIRVFRTAHELSMHTVAIYSYEDRLSMHRQKADESYPIGKVGQYSPVGAYLAIDEIVSIAKRTGANLVHPGYGFLSENAEFARKVNEAGMQFVGPSPEVIDSLGDKTKARAIAIRCGVPVVPGTPGPVEHYEEAEAFVKEYGLPVIIKAAMGGGGRGMRVVRSADTLKESFERARSEALASFGDGTVFIERFLDKPKHIEIQLMADKAGNVIHLHERDCSVQRRHQKVVEIAPAKDLDPKIRQALYDDAIKIAKEVKYCNAGTAEFLLDQKGRHYFIEINPRIQVEHTITEEITGVDIVSAQLHVAAGFTLPEIGLTQDKISTRGFAIQCRVTTEDPNNGFAPDIGKIEVYRSAGGNGVRLDGANGFAGSVITPHYDSMLVKCTCHDATYEYTRRKMIRSLIEFRVRGVKTNIPFVLRLLMHDTFIQGNCWTTFIDDTPELFQLYRSRNRAQKLLAYLGDLAVNGSSIKGQNGEPALKSEIVMPVLLDSTGNQIDVSHPSEKGWRKLLLDNGPAAFAKAVRNHKRGLIMDTTWRDAHQSLLATRVRTIDLVNIAPYTSHALASAYSLEMWGGATFDVSMRFLHECPWDRLRRLRKLVPNIPFQMLLRGANGLCYSSLPDNVIYFFCEQAKKNGIDIFRVFDALNDVNNLSLGIDAAKRAGGVVEATMCYSGDMLNPKKKYNLDYYVNLVDKMVEMGIHILGIKDMAGVMKPKAARLLISAIREKHPELPIHVHTHDSAGTAVASMAAALEAGADVVDVATDSMSGLTSQPSFGAVLASVDGTDKQLEFDNNQLREIDSYWAQMRLLYSPFESEIKGTDSDVYNHEIPGGQLTNLKFQATSLGLGTQWAETKKAYIEANKLLGDIIKVTPTSKVVGDLAQFMVQNKLSAEDVENRATTLDFPASVLDFFQGLMGQPYGGFPEPLRTNVLKGRRQPLTDRPGKFLPAADFDAIRKLLSEKFGVSSDCDIAAYTQFPGVFEEYRQFVDRYGDLTTVPTKFFLSRPEMNEEMHVEIDQGKTLIVKFVALGPLNPRTGQREVYFELNGENRHVTVEDKKAAIETVTRPRADPGNPGHVAAPMSGTIVEIRVKEGAKVKKGDIIAVLSAMKMEIVISAPHSGVLKSLAVVQGDSVNGGDLCAVLEHE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	DALLHNQSTNTNPFS HHHHCCCCCCCCCCH	29.01	24763107
14	Phosphorylation	ALLHNQSTNTNPFSK HHHCCCCCCCCCCHH	35.98	28889911
27	Phosphorylation	SKLQDRSSLLGEKFT HHHHCHHHHHCHHHH	28.62	25720772
207	Phosphorylation	RGMRVVRSADTLKES CCHHHHCCHHHHHHH	20.91	25720772
397	Phosphorylation	GKIEVYRSAGGNGVR CEEEEEECCCCCCEE	17.36	28889911
434	Phosphorylation	CTCHDATYEYTRRKM EECCCCCHHHHHHHH	14.52	28889911
437	Phosphorylation	HDATYEYTRRKMIRS CCCCHHHHHHHHHHH	16.44	28889911
444	Phosphorylation	TRRKMIRSLIEFRVR HHHHHHHHHHHHHHC	23.83	25720772
747	N6-carboxylysine	GIHILGIKDMAGVMK CCEECCCCHHCCCCC	39.39	-
747	Carboxylation	GIHILGIKDMAGVMK CCEECCCCHHCCCCC	39.39	-
861	Phosphorylation	FESEIKGTDSDVYNH CHHCCCCCCCCCCCC	27.59	21712547
863	Phosphorylation	SEIKGTDSDVYNHEI HCCCCCCCCCCCCCC	28.90	21712547
866	Phosphorylation	KGTDSDVYNHEIPGG CCCCCCCCCCCCCCC	18.78	24763107
1149	N6-biotinyllysine	IAVLSAMKMEIVISA EEEEECCCCEEEEEC	32.85	-
1149	Biotinylation	IAVLSAMKMEIVISA EEEEECCCCEEEEEC	32.85	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PYC_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PYC_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PYC_SCHPO !!

Protein-Protein Interaction

Oops, there are no PPI records of PYC_SCHPO !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.