PURB_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PURB_RAT
• UniProt AC: Q68A21
• Protein Name: Transcriptional activator protein Pur-beta
• Gene Name: Purb
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 315
• Subcellular Localization: Nucleus.
• Protein Description: Has capacity to bind repeated elements in single-stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene. Plays a role in the control of vascular smooth muscle (VSM) alpha-actin gene transcription as repressor in myoblasts and fibroblasts (By similarity). Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine-rich negative regulatory (PNR) element. Modulates constitutive liver galectin-3 gene transcription by binding to its promoter. May play a role in the dendritic transport of a subset of mRNAs..
• Protein Sequence: MADGDSGSERGGGGPGSFQPAPRGGGGPGGEQETQELASKRLDIQNKRFYLDVKQNAKGRFLKIAEVGAGGSKSRLTLSMAVAAEFRDSLGDFIEHYAQLGPSSPEQLAAGAEEGGGPRRALKSEFLVRENRKYYLDLKENQRGRFLRIRQTVNRGGGGFGGGPGPGGLQSGQTIALPAQGLIEFRDALAKLIDDYGGEDDELAGGPGGGAGGPGGGLYGELPEGTSITVDSKRFFFDVGCNKYGVFLRVSEVKPSYRNAITVPFKAWGKFGGAFCRYADEMKEIQERQRDKLYERRGGGSGGGDESEGEEVDED

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MADGDSGSE ------CCCCCCCCC	29.50	-
6	Phosphorylation	--MADGDSGSERGGG --CCCCCCCCCCCCC	50.15	27097102
8	Phosphorylation	MADGDSGSERGGGGP CCCCCCCCCCCCCCC	28.24	27097102
17	Phosphorylation	RGGGGPGSFQPAPRG CCCCCCCCCCCCCCC	24.68	27097102
23	Methylation	GSFQPAPRGGGGPGG CCCCCCCCCCCCCCC	59.50	-
34	Phosphorylation	GPGGEQETQELASKR CCCCHHHHHHHHHHH	27.34	-
54	Acetylation	KRFYLDVKQNAKGRF CEEEEECHHHCCCCE	37.19	22902405
63	Acetylation	NAKGRFLKIAEVGAG HCCCCEEEEEEECCC	36.84	22902405
89	Phosphorylation	VAAEFRDSLGDFIEH HHHHHHHHHHHHHHH	29.96	28689409
103	Phosphorylation	HYAQLGPSSPEQLAA HHHHHCCCCHHHHHH	57.64	27097102
104	Phosphorylation	YAQLGPSSPEQLAAG HHHHCCCCHHHHHHH	35.27	23712012
124	Phosphorylation	GPRRALKSEFLVREN CHHHHHHHHEEEECC	34.14	25575281
133	Acetylation	FLVRENRKYYLDLKE EEEECCCEEEEECCC	50.24	72589035
139	Acetylation	RKYYLDLKENQRGRF CEEEEECCCCCCCCE	55.04	22902405
155	Methylation	RIRQTVNRGGGGFGG EEEEEECCCCCCCCC	40.57	16185873
266	Acetylation	NAITVPFKAWGKFGG CCEEECCCHHHHCCH	36.84	22902405
270	Acetylation	VPFKAWGKFGGAFCR ECCCHHHHCCHHHHH	30.09	22902405
283	Acetylation	CRYADEMKEIQERQR HHHHHHHHHHHHHHH	50.01	22902405
292	Acetylation	IQERQRDKLYERRGG HHHHHHHHHHHCCCC	55.98	22902405
297	Methylation	RDKLYERRGGGSGGG HHHHHHCCCCCCCCC	35.85	-
301	Phosphorylation	YERRGGGSGGGDESE HHCCCCCCCCCCHHC	37.22	29779826
307	Phosphorylation	GSGGGDESEGEEVDE CCCCCCHHCCCCCCC	56.49	23712012

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PURB_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PURB_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PURB_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of PURB_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.