dbPTM

PURA_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PURA_SCHPO
UniProt AC	Q02787
Protein Name	Adenylosuccinate synthetase {ECO:0000255\|HAMAP-Rule:MF_03125}
Gene Name	ade2
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	434
Subcellular Localization	Cytoplasm .
Protein Description	Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP..
Protein Sequence	MASVRETGVNVSNDGITVVLGSQWGDEGKGKLVDILCDNVDVCARCQGGNNAGHTIVANGVTYDFHILPSGLVNPKCQNLIGSGVVVYLPAFFSELEKLEQKGLKCRDRIFISDRAHLVFDYHQRADALNEAELGKQSIGTTGKGIGPAYSTKATRSGIRVHHLYHWAEFEARYRKNVADLQKRYGAFEYDVEAELIRYKELAQRLKPFVIDAVAFMYEALQSKKRILVEGANALMLDLDFGTYPFVTSSNTTVGGVCTGLGVPPQRIANSIGVVKAYTTRVGAGPFPTEQLNEIGDHLQSVGREVGVTTGRKRRCGWLDLVVVKYSTMINGYTSLNLTKLDILDALDEIKVAVAYIINGKRIETFPADLDSLEEAEIVYETFPGWKVPTTGITHWDQMPENAKKYIEFIEKFVGVPITFIGVGPGRDEMLVKE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
138	Phosphorylation	EAELGKQSIGTTGKG HHHHCCCCCCCCCCC	26.86	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PURA_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PURA_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PURA_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
PUR6_SCHPO	ade6	genetic	1448066
PUR7_SCHPO	ade7	genetic	1448066

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PURA_SCHPO

Related Literatures of Post-Translational Modification