dbPTM

PURA_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PURA_DROME
UniProt AC	Q9Y0Y2
Protein Name	Adenylosuccinate synthetase {ECO:0000255\|HAMAP-Rule:MF_03125}
Gene Name	AdSS
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	447
Subcellular Localization	Cytoplasm .
Protein Description	Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity). Plays a role in the regulation of adult life span..
Protein Sequence	MSASATNGTHYEQLHQGRTKMYKSKVDVVLGAQWGDEGKGKVVDMLASDVDIVCRCQGGNNAGHTVVANGTEFDFHLLPSGVVNEKCVSVIGNGVVIHLPSLFDEVLKNEAKGLQHLENRLIISDRAHLVFDFHQHVDGMQEAEKGGKSLGTTKKGIGPAYSSKATRNGIRVGELLGDFNLFSEKFKSIVATHVRLFPSINVDVEAELARYKDYADKVRPYVKDTICFLHTALRNGKTILVEGANAAMLDIDFGTYPYVTSSNCSIGGVLTGLGLPPQTIGEVIGVVKAYTTRVGDGPFPTEQLNDIGDLLQTRGFEVGVTTKRKRRCGWLDIPLLKYTSLVNGYTCICLTKLDILDTLPEIKVAVAYKKPNGEKLDHFPGTIAELGNIEVEYAVLPGWQTSTEEVRNFKELPENAQSYVRLLESELSVPVRWVGVGKGRESIINVH

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSASATNGT ------CCCCCCCCC	30.82	19429919
4	Phosphorylation	----MSASATNGTHY ----CCCCCCCCCHH	28.46	19429919
442	Phosphorylation	GVGKGRESIINVH-- EECCCCCCEEECC--	27.66	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PURA_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PURA_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PURA_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PURA_DROME

Related Literatures of Post-Translational Modification