dbPTM

PUR2_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PUR2_DROME
UniProt AC	P00967
Protein Name	Trifunctional purine biosynthetic protein adenosine-3
Gene Name	ade3
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	1353
Subcellular Localization
Protein Description
Protein Sequence	MSHRVLVIGSGGREHAICWKLSQSPKVAQIYALPGSHGIQLVEKCRNLDAKTLDPKDFEAIAKWSKENQIALVVVGPEDPLALGLGDVLQSAGIPCFGPGKQGAQIEADKKWAKDFMLRHGIPTARYESFTDTEKAKAFIRSAPYPALVVKAAGLAAGKGVVVAANAKEACQAVDEILGDLKYGQAGATLVVEELLEGEEVSVLAFTDGKSVRAMLPAQDHKRLGNGDTGPNTGGMGAYCPCPLISQPALELVQKAVLERAVQGLIKERINYQGVLYAGLMLTRDGPRVLEFNCRFGDPETQVILPLLESDLFDVMEACCSGKLDKIPLQWRNGVSAVGVILASAGYPETSTKGCIISGLPAANTPTQLVFHSGLAVNAQKEALTNGGRVLIAIALDGSLKEAAAKATKLAGSISFSGSGAQYRTDIAQKAFKIASASTPGLSYKDSGVDIDAGDALVQRIKPLSRGTQRPGVIGGLGGFGGLFRLKELTYKEPVIAEATQGVGAKIHLALTHEFYENVGYDLFALAANDVLEVGAEPVAFLDYIACGKLQVPLAAQLVKGMADGCRDARCALVGGETAEMPSLYAPGQHDMAGYCVGIVEHSRILPRFDLYQPGDLLIGLPSSGLHCAGFNEILTQLAASKVNLRERSPVDGGDDGLTLAHVLATPTQLYVQQLLPHLQKGDEIKSVAHVTHGLLNDILRLLPDGFETTLDFGAVPVPKIFGWLAGKLKLSAQTILERHNCGIGMVLILPQSSQLWRTSLPGAKVLGVLQRRSKVSGSPVQVRNFVEQLEKVASPFGGLGDRELPEELKKLPSNSDLSAPREECFENAAGRRLTRIPTHYKDPILILGTDGVGTKLKIAQQTNRNTSVGIDLVAMCVNDILCNGAEPISFSSYYACGHWQEQLAKGVHSGVQEGARQANSSFIDSHSAALPLLYEPQVYDLAGFALGIAEHTGILPLLAEIQPGDVLIGLPSSGVHSNGFSLVHAVLKRVGLGLHDKAPFSDKTLGEELLVPTKIYVKALSTLLSRGKHGIKALAHITGGGLSENIPRVLRKDLAVRLDANKFQLPPVFAWLAAAGNISSTELQRTYNCGLGMVLVVAPTEVEDVLKELRYPQRAAVVGEVVARKDPKKSQVVVQNFEASLARTQKMLSQRRKRVAVLISGTGSNLQALIDATRDSAQGIHADVVLVISNKPGVLGLQRATQAGIPSLVISHKDFASREVYDAELTRNLKAARVDLICLAGFMRVLSAPFVREWRGRLVNIHPSLLPKYPGLHVQKQALEAGEKESGCTVHFVDEGVDTGAIIVQAAVPILPDDDEDSLTQRIHKAEHWAFPRALAMLVNGTALISPEVSSQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
135	Acetylation	ESFTDTEKAKAFIRS CCCCCHHHHHHHHHC	58.23	21791702
439	Phosphorylation	FKIASASTPGLSYKD HHHHCCCCCCCCCCC	22.54	21082442
814	Phosphorylation	EELKKLPSNSDLSAP HHHHCCCCCCCCCCC	60.44	19429919
816	Phosphorylation	LKKLPSNSDLSAPRE HHCCCCCCCCCCCHH	44.24	18327897

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PUR2_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PUR2_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PUR2_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of PUR2_DROME !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PUR2_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-814 AND SER-816, ANDMASS SPECTROMETRY.	18327897 [Abstract]