PUMP6_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PUMP6_ARATH
• UniProt AC: Q9FY68
• Protein Name: Mitochondrial uncoupling protein 6
• Gene Name: PUMP6
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 337
• Subcellular Localization: Mitochondrion inner membrane; Multi-pass membrane protein.
• Protein Description: PUMPS are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. This leads to a decrease in the efficiency of oxidative phosphorylation and an increase in heat production. May be involved in protecting plant cells against oxidative stress damage (By similarity). Recombinant PUMP6, reconstituted into liposomes, transports a wide range of dicarboxylic acids including malate, oxaloacetate and succinate as well as phosphate, sulfate and thiosulfate. However, it is unknown if these transports are of any biological significance in vivo..
• Protein Sequence: MGFKPFLEGGIAAIIAGALTHPLDLIKVRMQLQGEHSFSLDQNPNPNLSLDHNLPVKPYRPVFALDSLIGSISLLPLHIHAPSSSTRSVMTPFAVGAHIVKTEGPAALFSGVSATILRQMLYSATRMGIYDFLKRRWTDQLTGNFPLVTKITAGLIAGAVGSVVGNPADVAMVRMQADGSLPLNRRRNYKSVVDAIDRIARQEGVSSLWRGSWLTVNRAMIVTASQLATYDHVKEILVAGGRGTPGGIGTHVAASFAAGIVAAVASNPIDVVKTRMMNADKEIYGGPLDCAVKMVAEEGPMALYKGLVPTATRQGPFTMILFLTLEQVRGLLKDVKF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
244	Phosphorylation	LVAGGRGTPGGIGTH EEECCCCCCCCHHHH		27545962
250	Phosphorylation	GTPGGIGTHVAASFA CCCCCHHHHHHHHHH		27545962
255	Phosphorylation	IGTHVAASFAAGIVA HHHHHHHHHHHHHHH		27545962
266	Phosphorylation	GIVAAVASNPIDVVK HHHHHHHCCCHHHHH		27545962
274	Phosphorylation	NPIDVVKTRMMNADK CCHHHHHHEECCCCC		27545962

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PUMP6_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PUMP6_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PUMP6_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of PUMP6_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.