PTPRD_MOUSE - dbPTM
PTPRD_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PTPRD_MOUSE
UniProt AC Q64487
Protein Name Receptor-type tyrosine-protein phosphatase delta
Gene Name Ptprd
Organism Mus musculus (Mouse).
Sequence Length 1912
Subcellular Localization Membrane
Single-pass type I membrane protein.
Protein Description Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically. [PubMed: 25908590 Involved in pre-synaptic differentiation through interaction with SLITRK2]
Protein Sequence MVPVARPLSLLLTFFLCACAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEEPYKEIDGIATTRYSVAGLSPYSDYEFRVVAVNNIGRGPASEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIASYELVYRDGDQGEEQRITIEPGTSYRLQGLKPNSLYYFRLSARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSLKYAAVDGEDFKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTDEDVPSGPPRKVEVEAVNATAVKVSWRSPVPNKQHGQIRGYQVHYVKMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISVPEEIPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGVITKYTLLYRDINVPLLPMEHLIVPADTSMTLTGLKSDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPDVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMDHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESESRKSSLPNSKEVPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFCYRAALEYLGSFDHYAT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
252PhosphorylationHEIMPGGSVNITCVA
CCCCCCCCEEEEEEE		20.22-
254N-linked_GlycosylationIMPGGSVNITCVAVG
CCCCCCEEEEEEECC		26.0825908590
299N-linked_GlycosylationNDVRQSANYTCVAMS
HHHHHHCCCEEEEEE		37.5825908590
672PhosphorylationIPSDTTKYLLEQLEK
CCCHHHHHHHHHHHH		17.90-
683PhosphorylationQLEKWTEYRITVTAH
HHHHHCEEEEEEEEE		10.43-
724N-linked_GlycosylationKVEVEAVNATAVKVS
EEEEEEEECCEEEEE		38.32-
726PhosphorylationEVEAVNATAVKVSWR
EEEEEECCEEEEEEC		27.1223684622
832N-linked_GlycosylationGKPRLVINHTQMNTA
CCCEEEEECCCCCCE		25.36-
955PhosphorylationNGVITKYTLLYRDIN
CCEEEEEEEEECCCC		16.3125777480
980PhosphorylationVPADTSMTLTGLKSD
EECCCCEEEECCCCC		22.4225777480
982PhosphorylationADTSMTLTGLKSDTT
CCCCEEEECCCCCCE		31.1625777480
986PhosphorylationMTLTGLKSDTTYDVK
EEEECCCCCCEEEEE		45.2725777480
1080PhosphorylationVNLKPEKSYSFVLTN
EECCCCCEEEEEEEC		25.0924759943
1082PhosphorylationLKPEKSYSFVLTNRG
CCCCCEEEEEEECCC		18.9024759943
1297PhosphorylationYKRKRAESESRKSSL
HHHHHHHHHHHHCCC		39.6322324799
1299PhosphorylationRKRAESESRKSSLPN
HHHHHHHHHHCCCCC		55.0522324799
1302PhosphorylationAESESRKSSLPNSKE
HHHHHHHCCCCCCCC		35.6825521595
1303PhosphorylationESESRKSSLPNSKEV
HHHHHHCCCCCCCCC		51.3725521595
1307PhosphorylationRKSSLPNSKEVPSHH
HHCCCCCCCCCCCCC		28.4023335269
1308UbiquitinationKSSLPNSKEVPSHHP
HCCCCCCCCCCCCCC		70.1722790023
1308UbiquitinationKSSLPNSKEVPSHHP
HCCCCCCCCCCCCCC		70.1722790023
1381UbiquitinationHSNLEVNKPKNRYAN
CCCCEECCCCCCCEE		63.6522790023
1381UbiquitinationHSNLEVNKPKNRYAN
CCCCEECCCCCCCEE		63.6522790023
1386PhosphorylationVNKPKNRYANVIAYD
ECCCCCCCEEEEEEC		16.3629899451
1649UbiquitinationTGMELEFKRLASSKA
CCCEEEHHHHHCCCC		36.8122790023
1649UbiquitinationTGMELEFKRLASSKA
CCCEEEHHHHHCCCC		36.8122790023
1670UbiquitinationSANLPCNKFKNRLVN
HCCCCHHHCCCCCEE		65.5122790023
1670UbiquitinationSANLPCNKFKNRLVN
HCCCCHHHCCCCCEE		65.5122790023
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PTPRD_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PTPRD_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PTPRD_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of PTPRD_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PTPRD_MOUSE

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Related Literatures of Post-Translational Modification

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