PTPRC_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PTPRC_RAT
• UniProt AC: P04157
• Protein Name: Receptor-type tyrosine-protein phosphatase C
• Gene Name: Ptprc
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 1273
• Subcellular Localization: Membrane; Single-pass type I membrane protein. Membrane raft. Colocalized with DPP4 in membrane rafts..
• Protein Description: Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN (By similarity). Dephosphorylates LYN, and thereby modulates LYN activity (By similarity)..
• Protein Sequence: MYLWLKLLAFSLALLGPEVFVTGQGTTDDGLDTTEIVLLPQTDPLPARTTEFTPPSISERGNGSSETTYLPGFSSTLMPHLTPQPDSQTPSARGADTQTLSSQADLTTLTAAPSGETDPPGVPEESTVPETFPGGTPILARNSTAPSPTHTSNVSTTDISSGANLTTPAPSTLGFASNTTTSTEIATPQTKPSCDEKFGNVTVRYIYDDSSKNFNANLEGDKKPKCEYTDCEKELKNLPECSQKNVTLSNGSCTPDKIINLDVPPGTHNFNLTNCTPDIEANTSICLEWKIKNKFTCDIQKISYNFRCTPEMKTFALDKHGTLWLHNLTVRTNYTCAAEVLYNNVILLKQDRRVQTDFGTPEMLPHVQCKNSTNSTTLVSWAEPASKHHGYILCYKKTPSEKCENLANDVNSFEVKNLRPYTEYTVSLFAYVIGRVQRNGPAKDCNFRTKAARPGKVNGMKTSRASDNSINVTCNSPYEINGPEARYILEVKSGGSLVKTFNQSTCKFVVDNLYYSTDYEFLVYFYNGEYLGDPEIKPQSTSYNSKALIIFLVFLIIVTSIALLVVLYKIYDLRKKRSSNLDEQQELVERDEEKQLINVDPIHSDLLLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKDARKSQNQNKNRYVDILPYDYNRVELSEINGDAGSTYINASYIDGFKEPRKYIAAQGPRDETVDDFWKMIWEQKATVIVMVTRCEEGNRNKCAEYWPCMEEGTRTFRDVVVTINDHKRCPDYIIQKLSIAHKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLESLEAEGKVDVYGYVVNLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHSCLQNLKKRDPPSDPSPLEAEYQRLPSYRSWRTQHIGNQEENKKKNRSSNVVPYDFNRVPLKHELEMSKESEAESDESSDEDSDSEETSKYINASFVMSYWKPEMMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELMSGDQEVCAQYWGEGKQTYGDMEVMLKDTNKSSAYILRAFELRHSKRKEPRTVYQYQCTTWKGEELPAEPKDLVTLIQNIKQKLPKSGSEGMKYHKHASILVHCRDGSQQTGLFCALFNLLESAETEDVVDVFQVVKSLRKARPGMVGSFEQYQFLYDIMASIYPTQNGQVKKANSQDKIEFHNEVDGAKQDANCVQPADPLNKAQEDSKEVGASEPASGSEEPEHSANGPMSPALTPSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
62	N-linked_Glycosylation	PSISERGNGSSETTY CCHHHCCCCCCCCCC	54.09	-
142	N-linked_Glycosylation	GTPILARNSTAPSPT CCEEEEECCCCCCCC	37.80	-
153	N-linked_Glycosylation	PSPTHTSNVSTTDIS CCCCCCCCCCCCCCC	32.68	-
164	N-linked_Glycosylation	TDISSGANLTTPAPS CCCCCCCCCCCCCCC	41.25	-
178	N-linked_Glycosylation	STLGFASNTTTSTEI CCCCCCCCCCCCCCC	37.71	-
200	N-linked_Glycosylation	SCDEKFGNVTVRYIY CCCCCCCCEEEEEEE	29.44	-
245	N-linked_Glycosylation	LPECSQKNVTLSNGS CCHHHCCCEEECCCC	25.11	-
250	N-linked_Glycosylation	QKNVTLSNGSCTPDK CCCEEECCCCCCCCE	49.89	-
271	N-linked_Glycosylation	PPGTHNFNLTNCTPD CCCCCCCCCCCCCCC	51.80	-
282	N-linked_Glycosylation	CTPDIEANTSICLEW CCCCCCCCCEEEEEE	22.90	-
327	N-linked_Glycosylation	HGTLWLHNLTVRTNY CCEEEEEECEECCCC	34.93	-
333	N-linked_Glycosylation	HNLTVRTNYTCAAEV EECEECCCCEEHHHH	21.39	-
371	N-linked_Glycosylation	LPHVQCKNSTNSTTL CCCEEECCCCCCEEE	62.79	-
374	N-linked_Glycosylation	VQCKNSTNSTTLVSW EEECCCCCCEEEEEE	36.86	-
471	N-linked_Glycosylation	RASDNSINVTCNSPY CCCCCCEEEEECCCC	23.90	-
502	N-linked_Glycosylation	GSLVKTFNQSTCKFV CEEEEEECCCCCCEE	39.87	-
578	Phosphorylation	YDLRKKRSSNLDEQQ HHHHHHHCCCCHHHH	32.24	30181290
579	Phosphorylation	DLRKKRSSNLDEQQE HHHHHHCCCCHHHHH	45.50	30181290
612	Acetylation	DLLLETYKRKIADEG HHHHHHHHHHHHHCC	55.42	22902405
639	Acetylation	VFSKFPIKDARKSQN HHHCCCHHHHHHHCC	45.64	22902405
652	Phosphorylation	QNQNKNRYVDILPYD CCCCCCCEEEECCCC	16.33	22673903
756	Ubiquitination	VVTINDHKRCPDYII EEEECCCCCCCHHHH	59.57	-
938	Acetylation	IGNQEENKKKNRSSN CCCHHHHCCCCCCCC	69.29	22902405
943	Phosphorylation	ENKKKNRSSNVVPYD HHCCCCCCCCCCCCC	35.34	26437020
944	Phosphorylation	NKKKNRSSNVVPYDF HCCCCCCCCCCCCCC	30.33	29779826
949	Phosphorylation	RSSNVVPYDFNRVPL CCCCCCCCCCCCCCC	22.89	28689409
963	Phosphorylation	LKHELEMSKESEAES CCHHHHHCCCCCCCC	24.72	25532521
966	Phosphorylation	ELEMSKESEAESDES HHHHCCCCCCCCCCC	45.93	22673903
970	Phosphorylation	SKESEAESDESSDED CCCCCCCCCCCCCCC	54.44	22673903
973	Phosphorylation	SEAESDESSDEDSDS CCCCCCCCCCCCCCC	48.34	22673903
974	Phosphorylation	EAESDESSDEDSDSE CCCCCCCCCCCCCCH	42.86	22673903
978	Phosphorylation	DESSDEDSDSEETSK CCCCCCCCCCHHHHH	40.77	22673903
980	Phosphorylation	SSDEDSDSEETSKYI CCCCCCCCHHHHHHH	41.08	22673903
1060	Acetylation	GDMEVMLKDTNKSSA CCEEEEEECCCHHHH	44.40	22902405
1209	Phosphorylation	GQVKKANSQDKIEFH CCEEECCCCCCEEEE	44.61	29779826
1248	Phosphorylation	DSKEVGASEPASGSE HHCCCCCCCCCCCCC	37.88	22673903
1252	Phosphorylation	VGASEPASGSEEPEH CCCCCCCCCCCCCCC	54.27	22673903
1254	Phosphorylation	ASEPASGSEEPEHSA CCCCCCCCCCCCCCC	35.97	22673903
1260	Phosphorylation	GSEEPEHSANGPMSP CCCCCCCCCCCCCCC	23.05	22673903
1266	Phosphorylation	HSANGPMSPALTPSS CCCCCCCCCCCCCCC	15.34	22673903
1270	Phosphorylation	GPMSPALTPSS---- CCCCCCCCCCC----	24.19	22673903
1272	Phosphorylation	MSPALTPSS------ CCCCCCCCC------	43.37	22673903
1273	Phosphorylation	SPALTPSS------- CCCCCCCC-------	45.50	22673903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PTPRC_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PTPRC_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PTPRC_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of PTPRC_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.