PTPA_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PTPA_MOUSE
• UniProt AC: P58389
• Protein Name: Serine/threonine-protein phosphatase 2A activator
• Gene Name: Ptpa
• Organism: Mus musculus (Mouse).
• Sequence Length: 323
• Subcellular Localization: Cytoplasm. Nucleus.
• Protein Description: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+). Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in vitro). The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A(D):PPP2R4 complex. Is involved in apoptosis; the function appears to be independent from PP2A (By similarity)..
• Protein Sequence: MAEGERQPPPDSSEETPPTTQNFIIPKKEIHTVPDMGKWKRSQAYADYIGFILTLNEGVKGKKLTFDYKVSEAIEKLVALLDTLDRWIDETPPVDQPSRFGNKAYRTWYAKLDQEAENLVATVVPTHLAAAVPEVAVYLKEAVGNSTRIDYGTGHEAAFAAFLCCLCKIGVLRVDDQVAIVFKVFDRYLEVMRKLQKTYRMEPAGSQGVWGLDDFQFLPFIWGSSQLIDHPHLEPRHFVDEKAVSENHKDYMFLQCILFITEMKTGPFAEHSNQLWNISAVPSWSKVNQGLIRMYKAECLEKFPVIQHFKFGSLLPIHPVTSG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAEGERQPP ------CCCCCCCCC	33.24	-
12	Phosphorylation	ERQPPPDSSEETPPT CCCCCCCCCCCCCCC	45.48	25293948
13	Phosphorylation	RQPPPDSSEETPPTT CCCCCCCCCCCCCCC	47.00	25293948
16	Phosphorylation	PPDSSEETPPTTQNF CCCCCCCCCCCCCCC	30.43	25293948
19	Phosphorylation	SSEETPPTTQNFIIP CCCCCCCCCCCCEEE	42.07	25293948
20	Phosphorylation	SEETPPTTQNFIIPK CCCCCCCCCCCEEEC	27.56	25293948
103	Malonylation	QPSRFGNKAYRTWYA CCCCCCCHHHHHHHH	47.37	26320211
286	Acetylation	SAVPSWSKVNQGLIR ECCCCHHHHCHHHHH	38.66	23236377
296	Malonylation	QGLIRMYKAECLEKF HHHHHHHHHHHHHHC	28.50	26320211
296	Acetylation	QGLIRMYKAECLEKF HHHHHHHHHHHHHHC	28.50	22826441
302	Acetylation	YKAECLEKFPVIQHF HHHHHHHHCCEEEEE	41.86	22826441

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PTPA_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PTPA_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PTPA_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PTPA_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.