PTMA_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PTMA_RAT
• UniProt AC: P06302
• Protein Name: Prothymosin alpha
• Gene Name: Ptma
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 112
• Subcellular Localization: Nucleus.
• Protein Description: Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections..
• Protein Sequence: MSDAAVDTSSEITTKDLKEKKEVVEEAENGRDAPANGNAQNEENGEQEADNEVDEEEEEGGEEEEEEEEGDGEEEDGDEDEEAEAPTGKRVAEDDEDDDVETKKQKKTDEDD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MSDAAVDT -------CCCCCCCC	8.05	-
2	Acetylation	------MSDAAVDTS ------CCCCCCCCC	35.64	3855555
2	Phosphorylation	------MSDAAVDTS ------CCCCCCCCC	35.64	27097102
8	Phosphorylation	MSDAAVDTSSEITTK CCCCCCCCCCCCCHH	27.79	23298284
9	Phosphorylation	SDAAVDTSSEITTKD CCCCCCCCCCCCHHH	22.85	23298284
10	Phosphorylation	DAAVDTSSEITTKDL CCCCCCCCCCCHHHH	34.80	22673903
13	Phosphorylation	VDTSSEITTKDLKEK CCCCCCCCHHHHHHH	24.60	22673903
14	Phosphorylation	DTSSEITTKDLKEKK CCCCCCCHHHHHHHH	28.37	25575281
15	Acetylation	TSSEITTKDLKEKKE CCCCCCHHHHHHHHH	53.03	22902405
15	Succinylation	TSSEITTKDLKEKKE CCCCCCHHHHHHHHH	53.03	-
15	Succinylation	TSSEITTKDLKEKKE CCCCCCHHHHHHHHH	53.03	-
20	Acetylation	TTKDLKEKKEVVEEA CHHHHHHHHHHHHHH	53.28	22902405
102	Phosphorylation	DEDDDVETKKQKKTD CCCCCHHHHHHHCCC	43.31	-
103	Acetylation	EDDDVETKKQKKTDE CCCCHHHHHHHCCCC	39.44	-
103	Succinylation	EDDDVETKKQKKTDE CCCCHHHHHHHCCCC	39.44	26843850
108	Phosphorylation	ETKKQKKTDEDD--- HHHHHHCCCCCC---	52.21	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PTMA_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PTMA_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PTMA_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of PTMA_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Identification of a low-Mr acidic nuclear protein as prothymosinalpha.";
Palvimo J., Linnala-Kankkunen A.;
FEBS Lett. 277:257-260(1990).
Cited for: PARTIAL PROTEIN SEQUENCE.
PubMed: 2269362