PTBP2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PTBP2_MOUSE
• UniProt AC: Q91Z31
• Protein Name: Polypyrimidine tract-binding protein 2
• Gene Name: Ptbp2
• Organism: Mus musculus (Mouse).
• Sequence Length: 531
• Subcellular Localization: Nucleus .
• Protein Description: RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. In addition to its function in pre-mRNA splicing, plays also a role in the regulation of translation..
• Protein Sequence: MDGIVTEVAVGVKRGSDELLSGSVLSSPNSNMSGMVVTANGNDSKKFKGEDKMDGAPSRVLHIRKLPGEVTETEVIALGLPFGKVTNILMLKGKNQAFLELATEEAAITMVNYYSAVTPHLRNQPIYIQYSNHKELKTDNTLNQRAQVVLQAVTAVQTANTPLSGTTVSESAVTPAQSPVLRIIIDNMYYPVTLDVLHQIFSKFGAVLKIITFTKNNQFQALLQYGDPVNAQQAKLALDGQNIYNACCTLRIDFSKLVNLNVKYNNDKSRDYTRPDLPSGDGQPALDPAIAAAFAKETSLLAVPGALSPLAIPNAAAAAAAAAAGRVGMPGVSAGGNTVLLVSNLNEEMVTPQSLFTLFGVYGDVQRVKILYNKKDSALIQMADGNQSQLAMNHLNGQKMYGKIIRVTLSKHQTVQLPREGLDDQGLTKDFGNSPLHRFKKPGSKNFQNIFPPSATLHLSNIPPSVAEEDLRTLFANTGGTVKAFKFFQDHKMALLQMATVEEAIQALIDLHNYNLGENHHLRVSFSKSTI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDGIVTEV -------CCCCEEEE	10.85	-
16	Phosphorylation	AVGVKRGSDELLSGS ECEEECCCCCHHCCC	31.76	25293948
21	Phosphorylation	RGSDELLSGSVLSSP CCCCCHHCCCCCCCC	41.46	25293948
23	Phosphorylation	SDELLSGSVLSSPNS CCCHHCCCCCCCCCC	19.26	25293948
26	Phosphorylation	LLSGSVLSSPNSNMS HHCCCCCCCCCCCCC	41.41	27087446
27	Phosphorylation	LSGSVLSSPNSNMSG HCCCCCCCCCCCCCC	24.76	25521595
30	Phosphorylation	SVLSSPNSNMSGMVV CCCCCCCCCCCCEEE	36.98	25293948
33	Phosphorylation	SSPNSNMSGMVVTAN CCCCCCCCCEEEEEC	28.17	25521595
38	Phosphorylation	NMSGMVVTANGNDSK CCCCEEEEECCCCCC	11.73	25293948
298	Phosphorylation	AAAFAKETSLLAVPG HHHHHHCCCEEECCC	24.78	23984901
299	Phosphorylation	AAFAKETSLLAVPGA HHHHHCCCEEECCCC	23.60	23984901
308	Phosphorylation	LAVPGALSPLAIPNA EECCCCCCCCCCCCH	19.82	26824392
434	Phosphorylation	LTKDFGNSPLHRFKK CCCCCCCCCCCCCCC	29.26	28066266
444	Phosphorylation	HRFKKPGSKNFQNIF CCCCCCCCCCCCCCC	32.71	27681418
483	Ubiquitination	ANTGGTVKAFKFFQD HHCCCCEEEEEHHHH	48.20	22790023
483 (in isoform 2)	Ubiquitination	-	48.20	22790023
527	Phosphorylation	HHLRVSFSKSTI--- CEEEEEEECCCC---	20.42	29176673
529	Phosphorylation	LRVSFSKSTI----- EEEEEECCCC-----	30.09	23684622
530	Phosphorylation	RVSFSKSTI------ EEEEECCCC------	34.15	23684622

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PTBP2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PTBP2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PTBP2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PTBP2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteomic analysis of the developing mouse brain.";
Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.;
Mol. Cell. Proteomics 3:1093-1101(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-27 AND SER-308, AND MASSSPECTROMETRY.
PubMed: 15345747