PSME4_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PSME4_ARATH
• UniProt AC: F4JC97
• Protein Name: Proteasome activator subunit 4
• Gene Name: PA200
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 1811
• Protein Description: Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. involved in DNA damage response: binds to acetylated histones and promotes degradation of histones (By similarity)..
• Protein Sequence: MHLYNEWLPPPVAEETKKEKESFARVVRCVKELHRPDDPESVYATLKWISVIELFVRAKSELSVEDVSELVEIGLQIFHSSENKLYAQVRWGNVLVRLINKFRKKLSLKVQWRPLYDTLIHAHFSRSPGPEGWRLRQRHFMAVTSLIRSCRRFFPQGAASEIWSEFMSLLENPWHNSSFEGSGFVRLFLPTNPENQDFFSEKWIKNVLELWDSIPNCQFWNSQWTSVLARVIKNCSFIDWESYLPMLFSRFLNMFEVPVANGSGSYPFSVDVPRNTRFLFSNRTTTPSKSIAQSIVYFLKPGSSAHEQLEKLVNLLEQYYHPSNGGRWTYSLERFLLHLVIAFQKRLQREQQDPDSLPATCLGKPERVAFVGVVLKLIDRGQYSKNEHLSETVAAATSMLSYVEPSLVLPFVASRFHLALETTTATHQLKTAMMSVAFAGRSILQSSMSTAKSQDLGGDVDDRMFLDLIGISLSNALLGMDANDPPKTLATMQLIGSIFSNMAVLDDSSDDLSFMTMASFSEWLDEFLCRLIALLQHLEPNSVINEGLSSSATSGTFLVEDGPYYYCMLEILLGRLSGSLYNQALKKISKFVQTNILPGAIAEVGLLCCACVHSTPEEAVAQIVEPMLLAVISSLKEIPVNGYGGKGSAETLVSNKQDKQTLSPALEAAIDYQLKVLSVAITYGGSSLLPYKGLLIEAISSAFNSSSWKVNGAGDHLLRSLLGSLILYYPIDQYKCLSRHPAAPALEEWISTKASSKDEQVAHSRWHVPTQEETQFANELLDLHLQSALDDLLSICQSNIHSDAGDEKTHLKVTLLRIDSTLQGVLSCLPDFRPSPRHDMVEDLQFFIAGASGSCVGSAEIREKTAITIHAACKYLLEKKSDDSILLILIIRIMDALGNYGSLEYDEWSNHRQAWKLESAAIVEPPANFITEFNSKGKRRPRWALIDKAYMHNTWRSSQSSYHLFRTDGNFSPPEPLTFLVDDLLTLCLHNYETVRVLAGKSLIKLLKRWPQLLSKCVLSLTENLRKPDVQEYVVLGSCAILSSHSVLKHLTTDPKSFSSFLLGILSSSHHESMKSQKAIIELFVKYNIHFAGLSRNILRSLESHVEGSTSGDLVSQIGSMSFDSSSLHWRYNLMANRVLLLLVMSSRIDPSFSLKILDETAGHFLKNLKSQLPQTRILAISALNILLKESPHKMQGKDQPSVSSQETENANSSLDLALSQIFREEGFFKETFESLSHIHITDTDSSSRGNHGSSSFQSMADKSITRFYFEFSASWPRTPSWISLLGSDIFYPSFARIFKRLAQECGVPVLLALKSPLEEFCNAKERPKQCVAAEALAGVLHSDVNGLFNEWDSWIMVQLQNVILGQSVESIPEWAACIRYAVTGKGKQGTKIPVMRQQILDCIVAPLPPTATTTVVAKRYAFLSAALIELSPPKMPVTEVKLHIVLLDELICNMSHSSAQIREAIGVILSVLCSNIRLRMSYQQEYPTEEGKTDVDSQLKEENWFKLISAKASEAVKNIQQASISDSLDTSTDVDMGNAQSNGDSLDDVKWMETLFHFIISSFKSGRASYLLDVIAGFLYPVMSLQETSHKDLSILAKAAFELLKWRVFPESHLQKVIGVILSSADDSNWRIRSSTLTYLRTFMYRHTFILTHEDKQKIWKTVEKLLVDSQVEVREHAAAVLAGLMKGGDEDFAADFRDRSYAEANSIQKRRNRRKSSSTQSIAGVHGAVLGLVASVLSVPYDMPSWLPEHVTLLARFAGEPTPIKSTVTKAVAEFRRTHADTWNIQKDSFTEDQLEILADTSSSSSYFA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
60	Phosphorylation	ELFVRAKSELSVEDV HHHHHHCCCCCHHHH		23776212
63	Phosphorylation	VRAKSELSVEDVSEL HHHCCCCCHHHHHHH		23776212
68	Phosphorylation	ELSVEDVSELVEIGL CCCHHHHHHHHHHHH		23776212
80	Phosphorylation	IGLQIFHSSENKLYA HHHHHHCCCCCEEEE		23776212
81	Phosphorylation	GLQIFHSSENKLYAQ HHHHHCCCCCEEEEE		23776212
86	Phosphorylation	HSSENKLYAQVRWGN CCCCCEEEEEEHHHH		23776212
453	Phosphorylation	SSMSTAKSQDLGGDV HHHCHHHHHCCCCCC		29654922
648	Phosphorylation	NGYGGKGSAETLVSN CCCCCCCCHHHHHCC		25561503
1279	Phosphorylation	FSASWPRTPSWISLL ECCCCCCCCCHHHHH		24894044
1769	Phosphorylation	EPTPIKSTVTKAVAE CCCCCHHHHHHHHHH		19880383
1771	Phosphorylation	TPIKSTVTKAVAEFR CCCHHHHHHHHHHHH		19880383

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PSME4_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PSME4_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PSME4_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of PSME4_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.