PSMD8_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PSMD8_MOUSE
• UniProt AC: Q9CX56
• Protein Name: 26S proteasome non-ATPase regulatory subunit 8
• Gene Name: Psmd8
• Organism: Mus musculus (Mouse).
• Sequence Length: 353
• Protein Description: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair..
• Protein Sequence: MFIKGRAAKTPRGEPRRSSRGGRKLAVVAPPPVLGSTSRPHFRRESIARRRCRKSGRRLAASRKMAATAATVNGSTTVSSSGPAATSVGILQAAAGMYEQLKDEWNRKNPNLSKCGEELGRLKLVLLELNFLPTTGTKLTKQQLILARDILEIGAQWSILCKDIPSFERYMAQLKCYYFDYKEQLPESAYMHQLLGLNLLFLLSQNRVAEFHTELERLPAKDIQTNVYIKHPVSLEQYLMEGSYNKVFLAKGNIPAESYTFFIDILLDTIRDEIAGCIEKAYEKILFAEATRILFFSTPKKMTDYAKKRGWVLGPNNYYSFASQQQKPEDSTIPSTELAKQVIEYARQLEMIV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
114	Ubiquitination	RKNPNLSKCGEELGR HHCCCHHHHHHHHHH	49.80	22790023
138	Ubiquitination	FLPTTGTKLTKQQLI CCCCCCCCCCHHHHH	56.34	22790023
141	Ubiquitination	TTGTKLTKQQLILAR CCCCCCCHHHHHHHH	46.62	-
141	Acetylation	TTGTKLTKQQLILAR CCCCCCCHHHHHHHH	46.62	-
141	Malonylation	TTGTKLTKQQLILAR CCCCCCCHHHHHHHH	46.62	26320211
284	Acetylation	CIEKAYEKILFAEAT HHHHHHHHHHHHHHH	31.84	-
297	Phosphorylation	ATRILFFSTPKKMTD HHHHEEECCCCCHHH	36.14	27180971
298	Phosphorylation	TRILFFSTPKKMTDY HHHEEECCCCCHHHH	33.69	26745281
300	Ubiquitination	ILFFSTPKKMTDYAK HEEECCCCCHHHHHH	56.09	-
300	Malonylation	ILFFSTPKKMTDYAK HEEECCCCCHHHHHH	56.09	26320211
307	Malonylation	KKMTDYAKKRGWVLG CCHHHHHHHHCCEEC	36.45	26320211
340	Ubiquitination	IPSTELAKQVIEYAR CCHHHHHHHHHHHHH	58.69	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PSMD8_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PSMD8_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PSMD8_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PSMD8_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.