PSMD4_BOVIN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PSMD4_BOVIN
• UniProt AC: Q58DA0
• Protein Name: 26S proteasome non-ATPase regulatory subunit 4
• Gene Name: PSMD4
• Organism: Bos taurus (Bovine).
• Sequence Length: 382
• Protein Description: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMD4 acts as an ubiquitin receptor subunit through ubiquitin-interacting motifs and selects ubiquitin-conjugates for destruction. Displays a preferred selectivity for longer polyubiquitin chains..
• Protein Sequence: MVLESTMVCVDNSEYMRNGDFLPTRLQAQQDAVNIVCHSKTRSNPENNVGLITLANDCEVLTTLTPDTGRILSKLHTVQPKGKITFCTGIRVAHLALKHRQGKNHKMRIIAFVGSPVEDNEKDLVKLAKRLKKEKVNVDIINFGEEEVNTEKLTAFVNTLNGKDGTGSHLVTVPPGPSLADALISSPILAGEGGAMLGLGASDFEFGVDPSADPELALALRVSMEEQRQRQEEEARRAAAASAAEAGIATAGTEDSDDALLKMTISQQEFGRTGLPDLSSMTEEEQIAYAMQMSLQGAEFGQAESADMDASSAMDTSEPTKEEDDYDVMQDPEFLQSVLENLPGVDPNNEAIRNAMGSLASQATKDGKKDKKEEDKKEEDKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
250	Phosphorylation	AAEAGIATAGTEDSD HHHHCCCCCCCCCCH	24.57	-
253	Phosphorylation	AGIATAGTEDSDDAL HCCCCCCCCCCHHHH	33.87	-
256	Phosphorylation	ATAGTEDSDDALLKM CCCCCCCCHHHHHHH	31.03	-
266	Phosphorylation	ALLKMTISQQEFGRT HHHHHHHCHHHHHCC	19.35	-
358	Phosphorylation	AIRNAMGSLASQATK HHHHHHHHHHHHHHH	14.00	-
361	Phosphorylation	NAMGSLASQATKDGK HHHHHHHHHHHHCCC	26.16	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PSMD4_BOVIN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PSMD4_BOVIN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PSMD4_BOVIN !!

Protein-Protein Interaction

Oops, there are no PPI records of PSMD4_BOVIN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.