PSMD2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PSMD2_RAT
• UniProt AC: Q4FZT9
• Protein Name: 26S proteasome non-ATPase regulatory subunit 2
• Gene Name: Psmd2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 908
• Protein Description: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.; Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1..
• Protein Sequence: MEEGGRDKTPVQSQQPSATAPSGADEKSSGKERRDAGEKDKEQELSEEDKQLQDELEMLVERLGEKDTSLYRPALEELRRQIRSSTTSMTSVPKPLKFLRPHYGKLKEIYENMAPGENKCFAADIISVLAMTMSGERECLKYRLVGSQEELASWGHEYVRHLAGEVAKEWQELDDAEKAQREPLLTLVKEIVPYNMAHNAEHEACDLLMEIEQVDMLEKDIDENAYSKVCLYLTSCVNYVPEPENSALLRCALGVFRKFSRFPEALRLALMLNDMELVEDIFTSCKDVVVQKQMAFMLGRHGVFLELSEDVEEYEDLTEIMSNVQLNSNFLALARELDIMEPKVPDDIYKTHLENNRFGGSGSQVDSARMNLASSFVNGFVNAAFGQDKLLTDDGNKWLYKNKDHGMLSAAASLGMILLWDVDGGLTQIDKYLYSSEDYIKSGALLACGIVNSGVRNECDPALALLSDYVLHNSNTMRLGSIFGLGLAYAGSNREDVLTLLLPVMGDSKSSMEVAGVTALACGMIAVGSCNGDVTSTILQTIMEKSETELKDTYARWLPLGLGLNHLGKGEAIEAILAALEVVSEPFRSFANTLVDVCAYAGSGNVLKVQQLLHICSEHFDSKEKEEDKDKKEKKDKDKKEAPADMGAHQGVAVLGIALIAMGEEIGAEMALRTFGHLLRYGEPTLRRAVPLALALISVSNPRLNILDTLSKFSHDADPEVSYNSIFAMGMVGSGTNNARLAAMLRQLAQYHAKDPNNLFMVRLAQGLTHLGKGTLTLCPYHSDRQLMSQVAVAGLLTVLVSFLDVRNIILGKSHYVLYGLVAAMQPRMLVTFDEELRPLPVSVRVGQAVDVVGQAGKPKTITGFQTHTTPVLLAHGERAELATEEFLPVTPILEGFVILRKNPNYNL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEEGGRDK -------CCCCCCCC	10.77	-
9	Phosphorylation	EEGGRDKTPVQSQQP CCCCCCCCCCCCCCC	32.74	29779826
13	Phosphorylation	RDKTPVQSQQPSATA CCCCCCCCCCCCCCC	30.89	23984901
17	Phosphorylation	PVQSQQPSATAPSGA CCCCCCCCCCCCCCC	33.63	23984901
19	Phosphorylation	QSQQPSATAPSGADE CCCCCCCCCCCCCCC	43.36	23984901
22	Phosphorylation	QPSATAPSGADEKSS CCCCCCCCCCCCCCC	44.12	23984901
29	Phosphorylation	SGADEKSSGKERRDA CCCCCCCCCCCCCCC	66.02	28689409
105	Acetylation	FLRPHYGKLKEIYEN HHHCCCHHHHHHHHC	49.58	22902405
147	Phosphorylation	LKYRLVGSQEELASW HHHEECCCHHHHHHH	27.26	23984901
153	Phosphorylation	GSQEELASWGHEYVR CCHHHHHHHHHHHHH	46.33	28432305
158	Phosphorylation	LASWGHEYVRHLAGE HHHHHHHHHHHHHHH	9.34	28432305
194	Phosphorylation	LVKEIVPYNMAHNAE HHHHHHCCCCCCCCH	13.48	-
343	Acetylation	ELDIMEPKVPDDIYK HHCCCCCCCCCCHHH	53.76	22902405
361	Phosphorylation	ENNRFGGSGSQVDSA CCCCCCCCCHHHHHH	35.33	29779826
363	Phosphorylation	NRFGGSGSQVDSARM CCCCCCCHHHHHHHH	28.82	27097102
367	Phosphorylation	GSGSQVDSARMNLAS CCCHHHHHHHHHHHH	20.93	28432305
397	Acetylation	LLTDDGNKWLYKNKD EECCCCCEEEEECCC	44.07	22902405
432	Phosphorylation	GLTQIDKYLYSSEDY CCHHHHHHHHCCCHH	13.71	30181290
434	Phosphorylation	TQIDKYLYSSEDYIK HHHHHHHHCCCHHHH	13.68	30181290
435	Phosphorylation	QIDKYLYSSEDYIKS HHHHHHHCCCHHHHC	25.34	30181290
436	Phosphorylation	IDKYLYSSEDYIKSG HHHHHHCCCHHHHCC	22.41	30181290
551	Acetylation	EKSETELKDTYARWL HHCCCHHHHHHHHHH	41.62	-
754	Acetylation	QLAQYHAKDPNNLFM HHHHHHCCCCCCEEE	61.48	22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PSMD2_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PSMD2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PSMD2_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of PSMD2_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.