PSMD1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PSMD1_RAT
• UniProt AC: O88761
• Protein Name: 26S proteasome non-ATPase regulatory subunit 1
• Gene Name: Psmd1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 953
• Protein Description: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair..
• Protein Sequence: MITSAAGIISLLDEEEPQLKEFALHKLNAVVNDFWAEISESVDKIEVLYEDEGFRSRQFAALVASKVFYHLGAFEESLNYALGAGDLFNVNDNSEYVETIIAKCIDHYTKQCVENADLPEGEKKPIDQRLEGIVNKMFQRCLDDHKYKQAIGIALETRRLDVFEKTILESNDVPGMLAYSLKLCMSLMQNKQFRNKVLRVLVKIYMNLEKPDFINVCQCLIFLDDTQAVSDILEKLVKEDNLLMAYQICFDLYESASQQFLSSVIQNLRTVGTPIASVPGSTNTGTVPGPEKDSDSMETEEKTAGAVAGKTPDASPEPKDQTLKMIKILSGEMAIELHLQFLIRNNNTDLMILKNTKDAVRNSVCHTATVIANSFMHCGTTSDQFLRDNLEWLARATNWAKFTATASLGVIHKGHEKEALQLMATYLPKDTSPGSAYQEGGGLYALGLIHANHGGDIIDYLLNQLKNASNDIVRHGGSLGLGLAAMGTARQDVYDLLKTNLYQDDAVTGEAAGLALGLVMLGSKNTQAIEDMVGYAQETQHEKILRGLAVGIALVMYGRMEEADALIESLCRDKDPILRRSGMYTVAMAYCGSGNNKAIRRLLHVAVSDVNDDVRRAAVESLGFILFRTPEQCPSVVSLLSESYNPHVRYGAAMALGVCCAGTGNKEAINLLEPMTNDPVNYVRQGALIASALIMIQQTEITCPKVNQFRQLYSKVINDKHDDVMAKFGAILAQGILDAGGHNVTISLQSRTGHTHMPSVVGVLVFTQFWFWFPLSHFLSLAYTPTCIIGLNKDLKMPKVQYKSNCKPSTFAYPAPLEVPKEKEKEKVSTAVLSITAKAKKKEKEKEKKEEEKMEVDEAEKKEEKEKKKEPEPNFQLLDNPARVMPAQLKVLSMTETCRYQPFKPLSIGGIIILKDTSEDIEELVEPVAAHGPKIEEEEQEPEPPEPFEYIDD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MITSAAGI -------CCCCHHHH	7.32	-
270	Phosphorylation	SVIQNLRTVGTPIAS HHHHHHHCCCCCCCC	26.84	27097102
273	Phosphorylation	QNLRTVGTPIASVPG HHHHCCCCCCCCCCC	13.74	23712012
277	Phosphorylation	TVGTPIASVPGSTNT CCCCCCCCCCCCCCC	29.57	23984901
281	Phosphorylation	PIASVPGSTNTGTVP CCCCCCCCCCCCCCC	16.65	27097102
282	Phosphorylation	IASVPGSTNTGTVPG CCCCCCCCCCCCCCC	42.59	27097102
284	Phosphorylation	SVPGSTNTGTVPGPE CCCCCCCCCCCCCCC	34.03	27097102
286	Phosphorylation	PGSTNTGTVPGPEKD CCCCCCCCCCCCCCC	22.84	28689409
294	Phosphorylation	VPGPEKDSDSMETEE CCCCCCCCCCCCCCH	42.53	28689409
296	Phosphorylation	GPEKDSDSMETEEKT CCCCCCCCCCCCHHH	23.59	22817900
299	Phosphorylation	KDSDSMETEEKTAGA CCCCCCCCCHHHHHH	40.58	28689409
302	Ubiquitination	DSMETEEKTAGAVAG CCCCCCHHHHHHHCC	37.13	-
303	Phosphorylation	SMETEEKTAGAVAGK CCCCCHHHHHHHCCC	33.34	25403869
310	Ubiquitination	TAGAVAGKTPDASPE HHHHHCCCCCCCCCC	47.34	-
310	Acetylation	TAGAVAGKTPDASPE HHHHHCCCCCCCCCC	47.34	22902405
311	Phosphorylation	AGAVAGKTPDASPEP HHHHCCCCCCCCCCC	26.03	23712012
315	Phosphorylation	AGKTPDASPEPKDQT CCCCCCCCCCCCHHH	36.86	23712012
322	Phosphorylation	SPEPKDQTLKMIKIL CCCCCHHHHHHHHHH	38.18	23984901
691	Phosphorylation	RQGALIASALIMIQQ HHHHHHHHHHHHHHC	19.33	28689409
715	Acetylation	QFRQLYSKVINDKHD HHHHHHHHHHCCCHH	33.31	22902405
720	Acetylation	YSKVINDKHDDVMAK HHHHHCCCHHHHHHH	44.43	22902405
830	Phosphorylation	KEKEKVSTAVLSITA HHHHCCHHHHHHHHH	24.63	-
834	Phosphorylation	KVSTAVLSITAKAKK CCHHHHHHHHHHHHH	15.99	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PSMD1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PSMD1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PSMD1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of PSMD1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.