dbPTM

PSD4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PSD4_HUMAN
UniProt AC	Q8NDX1
Protein Name	PH and SEC7 domain-containing protein 4
Gene Name	PSD4
Organism	Homo sapiens (Human).
Sequence Length	1056
Subcellular Localization	Cell membrane . Cell projection, ruffle membrane . In interphase associated with the plasma membrane, in particular with membrane ruffling regions (PubMed:23603394). Accumulates in dynamic actin-rich membrane ruffles and microvilli-like structures (P
Protein Description	Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 4,5-bisphosphate..
Protein Sequence	MMGDYRLPDHPQPMEILNLYLGDSLEPHPGECPRETCSHEDPPEPFEEQTWATDPPEPTRQNVPPWGSGVELTHLGSWVHQDGLEPCQEQTRATDPPESTRQDAPPWGSGVELTHLGSPSAQREHRQNTASPGSPVNSHLPGSPKQNRSTSTQVVFWAGILQAQMCVLDLEEELEKTEGLKAGLKCCLPTPPVDLPGDTGLHSSPPENEDSGEDSSEPEGEGQAWLREGTPDSSPQWGAEEESMFFSNPLFLASPCSENSASGECFSWGASDSHAGVRTGPESPATLEPPLPEDTVLWELESEPDLGDGAAISGHCTPPFPVPIYKPHSICWASVAAAEGAPAAPPGHGESEGDRLGPAPSAAPCVDEALTWESGCVGSDLGPAAHPVQPWASLSPEGWQRGGPFWPQVTLNSQDRDEREGGHPQESLPCTLAPCPWRSPASSPEPSSPESESRGPGPRPSPASSQEGSPQLQHHSSGILPKWTLDASQSSLLETDGEQPSSLKKKEAGEAPKPGEEVKSEGTARPAETGDVQPDIHLTSAEHENLRTPMNSSWLPGSPMPQAQSPEEGQRPPAGDKLANGVRNNKVAWNLASRLYRLEGFRKSEVAAYLQKNNDFSRAVAEEYLSFFQFGGQSLDRALRSFLQALVLSGETQERERILYQFSRRFHHCNPGIFPSVDSVHTLTCAIMLLNTDLHGQNIGKSMSCQEFITNLNGLRDGGNFPKELLKALYWSIRSEKLEWAVDEEDTARPEKAQPSLPAGKMSKPFLQLAQDPTVPTYKQGILARKMHQDADGKKTPWGKRGWKMFHTLLRGMVLYFLKQGEDHCLEGESLVGQMVDEPVGVHHSLATPATHYTKKPHVFQLRTADWRLYLFQAPTAKEMSSWIARINLAAATHSAPPFPAAVGSQRRFVRPILPVGPAQSSLEEQHRSHENCLDAAADDLLDLQRNLPERRGRGRELEEHRLRKEYLEYEKTRYETYVQLLVARLHCPSDALDLWEEQLGREAGGTREPKLSLKKSHSSPSLHQDEAPTTAKVKRNISERRTYRKIIPKRNRNQL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Phosphorylation	PMEILNLYLGDSLEP CHHHHHHHCCCCCCC	13.94	27642862
24	Phosphorylation	LNLYLGDSLEPHPGE HHHHCCCCCCCCCCC	32.60	28348404
50	Phosphorylation	PEPFEEQTWATDPPE CCCCCCCCCCCCCCC	21.98	-
68	Phosphorylation	QNVPPWGSGVELTHL CCCCCCCCCEEEEEC	35.48	26074081
73	Phosphorylation	WGSGVELTHLGSWVH CCCCEEEEECCCCHH	11.10	26074081
77	Phosphorylation	VELTHLGSWVHQDGL EEEEECCCCHHCCCC	32.08	26657352
94	Phosphorylation	CQEQTRATDPPESTR HHHHHCCCCCCCCCC	45.83	26074081
99	Phosphorylation	RATDPPESTRQDAPP CCCCCCCCCCCCCCC	34.36	29978859
100	Phosphorylation	ATDPPESTRQDAPPW CCCCCCCCCCCCCCC	30.59	29978859
109	Phosphorylation	QDAPPWGSGVELTHL CCCCCCCCCCEEEEC	35.48	23401153
114	Phosphorylation	WGSGVELTHLGSPSA CCCCCEEEECCCHHH	11.10	22115753
118	Phosphorylation	VELTHLGSPSAQREH CEEEECCCHHHHHHH	23.26	23401153
120	Phosphorylation	LTHLGSPSAQREHRQ EEECCCHHHHHHHHH	38.44	22115753
129	Phosphorylation	QREHRQNTASPGSPV HHHHHHCCCCCCCCC	21.85	22115753
131	Phosphorylation	EHRQNTASPGSPVNS HHHHCCCCCCCCCHH	27.96	23401153
134	Phosphorylation	QNTASPGSPVNSHLP HCCCCCCCCCHHCCC	29.11	23401153
138	Phosphorylation	SPGSPVNSHLPGSPK CCCCCCHHCCCCCCC	27.00	20164059
143	Phosphorylation	VNSHLPGSPKQNRST CHHCCCCCCCCCCCC	27.30	23401153
181	Ubiquitination	LEKTEGLKAGLKCCL HHHCCCCCCCCCEEC	51.79	29967540
230	Phosphorylation	QAWLREGTPDSSPQW CCHHCCCCCCCCCCC	21.12	26074081
233	Phosphorylation	LREGTPDSSPQWGAE HCCCCCCCCCCCCCC	45.16	26074081
234	Phosphorylation	REGTPDSSPQWGAEE CCCCCCCCCCCCCCC	28.61	26074081
254	Phosphorylation	SNPLFLASPCSENSA CCCEEECCCCCCCCC	28.69	26074081
257	Phosphorylation	LFLASPCSENSASGE EEECCCCCCCCCCCC	43.10	26074081
260	Phosphorylation	ASPCSENSASGECFS CCCCCCCCCCCCCCC	21.54	26074081
271	Phosphorylation	ECFSWGASDSHAGVR CCCCCCCCCCCCCCC	35.39	26074081
273	Phosphorylation	FSWGASDSHAGVRTG CCCCCCCCCCCCCCC	16.85	26074081
279	Phosphorylation	DSHAGVRTGPESPAT CCCCCCCCCCCCCCC	55.47	26074081
283	Phosphorylation	GVRTGPESPATLEPP CCCCCCCCCCCCCCC	23.98	26074081
286	Phosphorylation	TGPESPATLEPPLPE CCCCCCCCCCCCCCC	34.73	26074081
295	Phosphorylation	EPPLPEDTVLWELES CCCCCCCCEEEEEEC	18.81	26074081
317	Phosphorylation	AAISGHCTPPFPVPI CEECCCCCCCCCCCC	28.46	20058876
371	Phosphorylation	PCVDEALTWESGCVG CCCCHHCCCCCCCCC	33.95	28348404
374	Phosphorylation	DEALTWESGCVGSDL CHHCCCCCCCCCCCC	29.11	28348404
379	Phosphorylation	WESGCVGSDLGPAAH CCCCCCCCCCCCCCC	14.84	28348404
393	Phosphorylation	HPVQPWASLSPEGWQ CCCCCCHHCCCCHHH	26.05	26074081
395	Phosphorylation	VQPWASLSPEGWQRG CCCCHHCCCCHHHCC	20.57	26074081
410	Phosphorylation	GPFWPQVTLNSQDRD CCCCCEEEECCCCCC	18.25	23186163
413	Phosphorylation	WPQVTLNSQDRDERE CCEEEECCCCCCCCC	36.25	23917254
431	Phosphorylation	PQESLPCTLAPCPWR CCCCCCCCEECCCCC	24.82	28348404
439	Phosphorylation	LAPCPWRSPASSPEP EECCCCCCCCCCCCC	22.43	28348404
442	Phosphorylation	CPWRSPASSPEPSSP CCCCCCCCCCCCCCC	50.22	30108239
443	Phosphorylation	PWRSPASSPEPSSPE CCCCCCCCCCCCCCC	35.07	30108239
447	Phosphorylation	PASSPEPSSPESESR CCCCCCCCCCCHHCC	57.79	28192239
448	Phosphorylation	ASSPEPSSPESESRG CCCCCCCCCCHHCCC	43.32	26657352
451	Phosphorylation	PEPSSPESESRGPGP CCCCCCCHHCCCCCC	44.23	30108239
453	Phosphorylation	PSSPESESRGPGPRP CCCCCHHCCCCCCCC	52.39	30108239
461	Phosphorylation	RGPGPRPSPASSQEG CCCCCCCCCCCCCCC	34.08	29978859
464	Phosphorylation	GPRPSPASSQEGSPQ CCCCCCCCCCCCCCC	35.62	28450419
465	Phosphorylation	PRPSPASSQEGSPQL CCCCCCCCCCCCCCC	34.06	28450419
469	Phosphorylation	PASSQEGSPQLQHHS CCCCCCCCCCCCCCC	14.55	28464451
476	Phosphorylation	SPQLQHHSSGILPKW CCCCCCCCCCCCCEE	28.30	28450419
477	Phosphorylation	PQLQHHSSGILPKWT CCCCCCCCCCCCEEE	26.04	28450419
484	Phosphorylation	SGILPKWTLDASQSS CCCCCEEEECHHHHH	22.38	29970186
488	Phosphorylation	PKWTLDASQSSLLET CEEEECHHHHHHCCC	30.20	22115753
490	Phosphorylation	WTLDASQSSLLETDG EEECHHHHHHCCCCC	22.06	30576142
491	Phosphorylation	TLDASQSSLLETDGE EECHHHHHHCCCCCC	29.36	22115753
495	Phosphorylation	SQSSLLETDGEQPSS HHHHHCCCCCCCCCC	49.64	30576142
501	Phosphorylation	ETDGEQPSSLKKKEA CCCCCCCCCCCHHHC	48.25	29978859
502	Phosphorylation	TDGEQPSSLKKKEAG CCCCCCCCCCHHHCC	51.39	29978859
548	Phosphorylation	AEHENLRTPMNSSWL HHCCCCCCCCCCCCC	30.01	-
552	Phosphorylation	NLRTPMNSSWLPGSP CCCCCCCCCCCCCCC	19.35	19845377
553	Phosphorylation	LRTPMNSSWLPGSPM CCCCCCCCCCCCCCC	27.85	19845377
558	Phosphorylation	NSSWLPGSPMPQAQS CCCCCCCCCCCCCCC	18.98	19845377
565	Phosphorylation	SPMPQAQSPEEGQRP CCCCCCCCCCCCCCC	36.98	24850871
586	Ubiquitination	ANGVRNNKVAWNLAS HHCHHCCHHHHHHHH	36.56	-
603	Ubiquitination	YRLEGFRKSEVAAYL HHHHCCCHHHHHHHH	49.02	29967540
604	Phosphorylation	RLEGFRKSEVAAYLQ HHHCCCHHHHHHHHH	32.80	30108239
609	Phosphorylation	RKSEVAAYLQKNNDF CHHHHHHHHHHCCHH	10.42	30108239
663	Phosphorylation	ERILYQFSRRFHHCN HHHHHHHHHHHHCCC	13.66	24719451
723	Ubiquitination	RDGGNFPKELLKALY CCCCCCCHHHHHHHH	57.78	29967540
752	Ubiquitination	EDTARPEKAQPSLPA CCCCCHHHCCCCCCC	55.81	29967540
761	Acetylation	QPSLPAGKMSKPFLQ CCCCCCCCCCHHHHH	41.95	25953088
761	Ubiquitination	QPSLPAGKMSKPFLQ CCCCCCCCCCHHHHH	41.95	29967540
763	Phosphorylation	SLPAGKMSKPFLQLA CCCCCCCCHHHHHHH	40.43	28857561
764	Ubiquitination	LPAGKMSKPFLQLAQ CCCCCCCHHHHHHHC	35.97	29967540
779	Ubiquitination	DPTVPTYKQGILARK CCCCCHHHHCHHHHH	44.52	29967540
786	Ubiquitination	KQGILARKMHQDADG HHCHHHHHCCCCCCC	34.82	29967540
808	Phosphorylation	RGWKMFHTLLRGMVL HHHHHHHHHHHHHHH	19.07	-
816	Phosphorylation	LLRGMVLYFLKQGED HHHHHHHHHHHCCCC	8.75	-
870	Phosphorylation	RTADWRLYLFQAPTA ECCCEEEEEEECCCH	9.26	27461979
876	Phosphorylation	LYLFQAPTAKEMSSW EEEEECCCHHHHHHH	54.07	27461979
881	Phosphorylation	APTAKEMSSWIARIN CCCHHHHHHHHHHHH	24.50	27461979
882	Phosphorylation	PTAKEMSSWIARINL CCHHHHHHHHHHHHH	22.61	27461979
905	Phosphorylation	PFPAAVGSQRRFVRP CCCCCCCCCCCCEEE	17.57	28857561
921	Phosphorylation	LPVGPAQSSLEEQHR CCCCCCCCCHHHHHH	38.71	27080861
922	Phosphorylation	PVGPAQSSLEEQHRS CCCCCCCCHHHHHHC	27.93	27080861
975	Phosphorylation	LEYEKTRYETYVQLL HHHHHHHHHHHHHHH	20.18	-
1013	Phosphorylation	GTREPKLSLKKSHSS CCCCCCCCCCCCCCC	44.24	30576142
1016	Ubiquitination	EPKLSLKKSHSSPSL CCCCCCCCCCCCCCC	59.71	29967540
1017	Phosphorylation	PKLSLKKSHSSPSLH CCCCCCCCCCCCCCC	27.32	23401153
1019	Phosphorylation	LSLKKSHSSPSLHQD CCCCCCCCCCCCCCC	51.54	23927012
1020	Phosphorylation	SLKKSHSSPSLHQDE CCCCCCCCCCCCCCC	17.06	23401153
1022	Phosphorylation	KKSHSSPSLHQDEAP CCCCCCCCCCCCCCC	40.19	23401153
1030	Phosphorylation	LHQDEAPTTAKVKRN CCCCCCCCCHHHHCH	46.57	23927012
1031	Phosphorylation	HQDEAPTTAKVKRNI CCCCCCCCHHHHCHH	24.34	24702127
1039	Phosphorylation	AKVKRNISERRTYRK HHHHCHHHHHHCHHH	28.71	26074081
1043	Phosphorylation	RNISERRTYRKIIPK CHHHHHHCHHHHCCC	33.62	-
1046	Ubiquitination	SERRTYRKIIPKRNR HHHHCHHHHCCCCCC	34.28	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PSD4_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PSD4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PSD4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
USP9X_HUMAN	USP9X	physical	20339350

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PSD4_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-491 AND SER-1019, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-129; SER-131 ANDSER-143, AND MASS SPECTROMETRY.	19369195 [Abstract]