PSD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PSD1_HUMAN
• UniProt AC: A5PKW4
• Protein Name: PH and SEC7 domain-containing protein 1
• Gene Name: PSD
• Organism: Homo sapiens (Human).
• Sequence Length: 1024
• Subcellular Localization: Cell membrane . Cell projection, ruffle membrane . Cleavage furrow . Distributed uniformly on the plasma membrane, as well as throughout the cytoplasm during metaphase. Subsequently concentrated at patches in the equatorial region at the onset of cyt
• Protein Description: Guanine nucleotide exchange factor for ARF6. [PubMed: 23603394 Induces cytoskeletal remodeling (By similarity]
• Protein Sequence: MAQGAMRFCSEGDCAISPPRCPRRWLPEGPVPQSPPASMYGSTGSLLRRVAGPGPRGRELGRVTAPCTPLRGPPSPRVAPSPWAPSSPTGQPPPGAQSSVVIFRFVEKASVRPLNGLPAPGGLSRSWDLGGVSPPRPTPALGPGSNRKLRLEASTSDPLPARGGSALPGSRNLVHGPPAPPQVGADGLYSSLPNGLGGPPERLATLFGGPADTGFLNQGDTWSSPREVSSHAQRIARAKWEFFYGSLDPPSSGAKPPEQAPPSPPGVGSRQGSGVAVGRAAKYSETDLDTVPLRCYRETDIDEVLAEREEADSAIESQPSSEGPPGTAYPPAPRPGPLPGPHPSLGSGNEDEDDDEAGGEEDVDDEVFEASEGARPGSRMPLKSPVPFLPGTSPSADGPDSFSCVFEAILESHRAKGTSYTSLASLEALASPGPTQSPFFTFELPPQPPAPRPDPPAPAPLAPLEPDSGTSSAADGPWTQRGEEEEAEARAKLAPGREPPSPCHSEDSLGLGAAPLGSEPPLSQLVSDSDSELDSTERLALGSTDTLSNGQKADLEAAQRLAKRLYRLDGFRKADVARHLGKNNDFSKLVAGEYLKFFVFTGMTLDQALRVFLKELALMGETQERERVLAHFSQRYFQCNPEALSSEDGAHTLTCALMLLNTDLHGHNIGKRMTCGDFIGNLEGLNDGGDFPRELLKALYSSIKNEKLQWAIDEEELRRSLSELADPNPKVIKRISGGSGSGSSPFLDLTPEPGAAVYKHGALVRKVHADPDCRKTPRGKRGWKSFHGILKGMILYLQKEEYKPGKALSETELKNAISIHHALATRASDYSKRPHVFYLRTADWRVFLFQAPSLEQMQSWITRINVVAAMFSAPPFPAAVSSQKKFSRPLLPSAATRLSQEEQVRTHEAKLKAMASELREHRAAQLGKKGRGKEAEEQRQKEAYLEFEKSRYSTYAALLRVKLKAGSEELDAVEAALAQAGSTEDGLPPSHSSPSLQPKPSSQPRAQRHSSEPRPGAGSGRRKP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	SEGDCAISPPRCPRR CCCCCCCCCCCCCCC	15.44	27486199
34	Phosphorylation	PEGPVPQSPPASMYG CCCCCCCCCCHHHHC	27.12	24076635
38	Phosphorylation	VPQSPPASMYGSTGS CCCCCCHHHHCCHHH	20.50	27251275
42	Phosphorylation	PPASMYGSTGSLLRR CCHHHHCCHHHHHHH	16.47	27251275
43	Phosphorylation	PASMYGSTGSLLRRV CHHHHCCHHHHHHHH	26.82	27251275
45	Phosphorylation	SMYGSTGSLLRRVAG HHHCCHHHHHHHHCC	25.07	27251275
87	Phosphorylation	PSPWAPSSPTGQPPP CCCCCCCCCCCCCCC	25.97	25332170
89	Phosphorylation	PWAPSSPTGQPPPGA CCCCCCCCCCCCCCC	50.85	25332170
126	Phosphorylation	APGGLSRSWDLGGVS CCCCCCCCCCCCCCC	22.90	24076635
133	Phosphorylation	SWDLGGVSPPRPTPA CCCCCCCCCCCCCCC	32.25	24076635
138	Phosphorylation	GVSPPRPTPALGPGS CCCCCCCCCCCCCCC	23.60	25307156
154	Phosphorylation	RKLRLEASTSDPLPA CEEEEEEECCCCCCC	21.04	27732954
155	Phosphorylation	KLRLEASTSDPLPAR EEEEEEECCCCCCCC	44.17	27732954
156	Phosphorylation	LRLEASTSDPLPARG EEEEEECCCCCCCCC	34.43	27732954
189	Phosphorylation	QVGADGLYSSLPNGL CCCCCCHHHCCCCCC	11.18	24076635
190	Phosphorylation	VGADGLYSSLPNGLG CCCCCHHHCCCCCCC	30.37	27732954
191	Phosphorylation	GADGLYSSLPNGLGG CCCCHHHCCCCCCCC	34.00	24076635
224	Phosphorylation	NQGDTWSSPREVSSH CCCCCCCCHHHHHHH	21.38	24076635
263	Phosphorylation	PPEQAPPSPPGVGSR CCHHCCCCCCCCCCC	42.54	24076635
269	Phosphorylation	PSPPGVGSRQGSGVA CCCCCCCCCCCCCCE	21.01	24076635
283	Phosphorylation	AVGRAAKYSETDLDT EECCCCCCCCCCCCC	13.65	27732954
284	Phosphorylation	VGRAAKYSETDLDTV ECCCCCCCCCCCCCC	33.06	27732954
286	Phosphorylation	RAAKYSETDLDTVPL CCCCCCCCCCCCCCC	35.60	27732954
543	Phosphorylation	TERLALGSTDTLSNG HHHHHCCCCCCCCCC	24.78	25307156
622	Phosphorylation	ELALMGETQERERVL HHHHCCCHHHHHHHH	29.96	23403867
700	Phosphorylation	RELLKALYSSIKNEK HHHHHHHHHHHCCCC	12.77	22817900
720	Phosphorylation	DEEELRRSLSELADP CHHHHHHHHHHHCCC	29.79	27732954
722	Phosphorylation	EELRRSLSELADPNP HHHHHHHHHHCCCCC	31.63	27732954
736	Phosphorylation	PKVIKRISGGSGSGS CCCEEECCCCCCCCC	40.93	26657352
796	Phosphorylation	ILKGMILYLQKEEYK HHHHHHHHHHHHHCC	9.00	20049867
825	Phosphorylation	SIHHALATRASDYSK HHHHHHHHCCHHCCC	27.84	-
910	Methylation	QVRTHEAKLKAMASE HHHHHHHHHHHHHHH	47.76	-
912	Methylation	RTHEAKLKAMASELR HHHHHHHHHHHHHHH	35.10	-
992	Phosphorylation	DGLPPSHSSPSLQPK CCCCCCCCCCCCCCC	48.56	15345747
993	Phosphorylation	GLPPSHSSPSLQPKP CCCCCCCCCCCCCCC	17.06	15345747
1001	Phosphorylation	PSLQPKPSSQPRAQR CCCCCCCCCCCCHHH	47.97	15345747
1011	Phosphorylation	PRAQRHSSEPRPGAG CCHHHCCCCCCCCCC	45.56	23312004
1019	Phosphorylation	EPRPGAGSGRRKP-- CCCCCCCCCCCCC--	28.70	23312004

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PSD1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PSD1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PSD1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GNAQ_HUMAN	GNAQ	physical	17846866

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.