PSD13_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PSD13_RAT
• UniProt AC: B0BN93
• Protein Name: 26S proteasome non-ATPase regulatory subunit 13 {ECO:0000250|UniProtKB:Q9UNM6, ECO:0000312|EMBL:AAI58733.1}
• Gene Name: Psmd13 {ECO:0000312|EMBL:AAI58733.1, ECO:0000312|RGD:1305236}
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 376
• Protein Description: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair..
• Protein Sequence: MKDVPAFLQQSQSSGPGQAAVWHRLEELYTKKLWHQLTLQVLDFVQDPCFAQGDGLIKLYENFISEFEHRVNPLSLVEIILHVVRQMTDPNVALTFLEKTREKVKSSDEAVILCKTAIGALKLNIGDLQATKETIEDVEEMLNNLPGVTSVHSRFYDLSSKYYQTIGNHASYYKDALRFLGCVDIKDLPVSEQQERAFTLGLAGLLGEGVFNFGELLMHPVLESLRNTDRQWLIDTLYAFNSGDVDRFQTLKSAWGQQPDLAANEAQLLRKIQLLCLMEMTFTRPANHRQLTFEEIAKSAKITVNKVELLVMKALSVGLVRGSIDEVDKRVHMTWVQPRVLDLQQIKGMKDRLELWCTDVKSMELLVEHQAQDILT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
115	Ubiquitination	DEAVILCKTAIGALK CHHHHHCHHHHHHHH	37.23	-
122	Ubiquitination	KTAIGALKLNIGDLQ HHHHHHHHCCHHCHH	38.67	-
161	Ubiquitination	RFYDLSSKYYQTIGN HHHCCCCCHHHHHCC	44.60	-
186	Ubiquitination	FLGCVDIKDLPVSEQ HCCCEECCCCCCCHH	49.07	-
298	Acetylation	LTFEEIAKSAKITVN CCHHHHHHHCCCEEC	57.52	22902405
323	Phosphorylation	SVGLVRGSIDEVDKR HHCCCCCCHHHHHHH	19.12	28432305
329	Acetylation	GSIDEVDKRVHMTWV CCHHHHHHHHHHHEE	62.59	22902405
347	Acetylation	VLDLQQIKGMKDRLE CCCHHHHCCCHHHHH	48.92	22902405
362	Phosphorylation	LWCTDVKSMELLVEH HHCCCHHHHHHHHHH	19.82	27097102

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PSD13_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PSD13_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PSD13_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of PSD13_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.