PSA6_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PSA6_RAT
• UniProt AC: P60901
• Protein Name: Proteasome subunit alpha type-6
• Gene Name: Psma6
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 246
• Subcellular Localization: Cytoplasm . Nucleus . Colocalizes with TRIM5 in cytoplasmic bodies.
• Protein Description: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)..
• Protein Sequence: MSRGSSAGFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKLLDSSTVTHLFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIADISQVYTQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKKVKKKFDWTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRILTEAEIDAHLVALAERD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	O-linked_Glycosylation	---MSRGSSAGFDRH ---CCCCCCCCCCCE	18.86	-
17	Phosphorylation	DRHITIFSPEGRLYQ CCEEEEECCCCCEEE	20.42	-
23	Phosphorylation	FSPEGRLYQVEYAFK ECCCCCEEEEEEHHH	14.78	-
45	Succinylation	TSVAVRGKDCAVIVT EEEEECCCCEEEEEE	38.78	26843850
59	Acetylation	TQKKVPDKLLDSSTV ECCCCCHHHCCCCHH	44.90	22902405
63	Phosphorylation	VPDKLLDSSTVTHLF CCHHHCCCCHHHHHH	28.07	-
64	Phosphorylation	PDKLLDSSTVTHLFK CHHHCCCCHHHHHHH	26.94	-
96	Phosphorylation	SQVQRARYEAANWKY HHHHHHHHHHHCCHH	14.67	-
102	Acetylation	RYEAANWKYKYGYEI HHHHHCCHHHCCCCC	31.50	-
102	Ubiquitination	RYEAANWKYKYGYEI HHHHHCCHHHCCCCC	31.50	-
104	Acetylation	EAANWKYKYGYEIPV HHHCCHHHCCCCCCH	28.59	22902405
105	Phosphorylation	AANWKYKYGYEIPVD HHCCHHHCCCCCCHH	23.11	25575281
107	Phosphorylation	NWKYKYGYEIPVDML CCHHHCCCCCCHHHH	13.95	25575281
159	Phosphorylation	YKCDPAGYYCGFKAT EEECCCCCCCCEEEE	9.55	-
171	Ubiquitination	KATAAGVKQTESTSF EEEECCCCCCCCCCH	51.05	-
175	Phosphorylation	AGVKQTESTSFLEKK CCCCCCCCCCHHHHH	32.51	23984901
176	Phosphorylation	GVKQTESTSFLEKKV CCCCCCCCCHHHHHH	19.77	23984901
177	Phosphorylation	VKQTESTSFLEKKVK CCCCCCCCHHHHHHH	36.79	23984901
181	Acetylation	ESTSFLEKKVKKKFD CCCCHHHHHHHHHCC	66.08	22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PSA6_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PSA6_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PSA6_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of PSA6_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.