PSA4A_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PSA4A_ARATH
• UniProt AC: O81148
• Protein Name: Proteasome subunit alpha type-4-A
• Gene Name: PAC1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 250
• Subcellular Localization: Cytoplasm. Nucleus.
• Protein Description: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity..
• Protein Sequence: MSRRYDSRTTIFSPEGRLYQVEYAMEAIGNAGSAIGILSKDGVVLIGEKKVTSKLLQTSTSAEKMYKIDDHVACAVAGIMSDANILINTARVQAQRYTFMYQEPMPVEQLVQSLCDTKQGYTQFGGLRPFGVSFLFAGWDKHHGFQLYMSDPSGNYGGWKAAAVGANNQAAQSILKQDYKDDATREEAVELALKVLTKTMDSTSLTSEKLELAEVYLTPSKTVKYHVHSPESLTKLLVKHGVTQPAAETS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
33	Phosphorylation	EAIGNAGSAIGILSK HHHCCCCCCEEEEEC		24894044
40	Ubiquitination	SAIGILSKDGVVLIG CCEEEEECCCEEEEC		20516081
52	Phosphorylation	LIGEKKVTSKLLQTS EECCCCCHHHHHCCC		27545962
53	Phosphorylation	IGEKKVTSKLLQTST ECCCCCHHHHHCCCC		27545962
58	Phosphorylation	VTSKLLQTSTSAEKM CHHHHHCCCCCHHHH		27545962
59	Phosphorylation	TSKLLQTSTSAEKMY HHHHHCCCCCHHHHH		27545962
60	Phosphorylation	SKLLQTSTSAEKMYK HHHHCCCCCHHHHHC		27545962
61	Phosphorylation	KLLQTSTSAEKMYKI HHHCCCCCHHHHHCC		27545962
200	Sulfoxidation	LKVLTKTMDSTSLTS HHHHHHCCCCCCCCC		25693801
218	Phosphorylation	ELAEVYLTPSKTVKY EEEEEEECCCCEEEE		23328941
220	Phosphorylation	AEVYLTPSKTVKYHV EEEEECCCCEEEEEE		23328941
225	Phosphorylation	TPSKTVKYHVHSPES CCCCEEEEEECCHHH		28295753
229	Phosphorylation	TVKYHVHSPESLTKL EEEEEECCHHHHHHH		28295753
232	Phosphorylation	YHVHSPESLTKLLVK EEECCHHHHHHHHHH		28295753
234	Phosphorylation	VHSPESLTKLLVKHG ECCHHHHHHHHHHCC		19880383

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PSA4A_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PSA4A_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PSA4A_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of PSA4A_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.