PSA2_BOVIN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PSA2_BOVIN
• UniProt AC: Q3T0Y5
• Protein Name: Proteasome subunit alpha type-2
• Gene Name: PSMA2
• Organism: Bos taurus (Bovine).
• Sequence Length: 234
• Subcellular Localization: Cytoplasm . Nucleus . Colocalizes with TRIM5 in cytoplasmic bodies.
• Protein Description: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)..
• Protein Sequence: MAERGYSFSLTTFSPSGKLVQIEYALAAVAGGAPSVGIKAANGVVLATEKKQKSILYDERSVHKVEPITKHIGLVYSGMGPDYRVLVHRARKLAQQYYLVYQEPIPTAQLVQRVASVMQEYTQSGGVRPFGVSLLICGWNEGRPYLFQSDPSGAYFAWKATAMGKNYVNGKTFLEKRYNEDLELEDAIHTAILTLKESFEGQMTEDNIEVGICNEAGFRRLTPTEVKDYLAAIA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAERGYSFS ------CCCCCCEEE	18.39	-
6	Phosphorylation	--MAERGYSFSLTTF --CCCCCCEEEEEEE	16.86	-
7	Phosphorylation	-MAERGYSFSLTTFS -CCCCCCEEEEEEEC	15.93	-
14	Phosphorylation	SFSLTTFSPSGKLVQ EEEEEEECCCCCEEE	18.96	-
16	Phosphorylation	SLTTFSPSGKLVQIE EEEEECCCCCEEEEH	47.57	-
24	Phosphorylation	GKLVQIEYALAAVAG CCEEEEHHHHHHHHC	14.45	-
70	Acetylation	HKVEPITKHIGLVYS CCCCCCHHHEEEEEC	33.66	-
76	Phosphorylation	TKHIGLVYSGMGPDY HHHEEEEECCCCCCH	12.44	-
121	Phosphorylation	VASVMQEYTQSGGVR HHHHHHHHHHCCCCC	8.00	-
171	Acetylation	GKNYVNGKTFLEKRY CCCCCCCEEHHHHHH	30.79	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PSA2_BOVIN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PSA2_BOVIN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PSA2_BOVIN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PSMF1_HUMAN	PSMF1	physical	24770418

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.