PSA1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PSA1_RAT
• UniProt AC: P18420
• Protein Name: Proteasome subunit alpha type-1
• Gene Name: Psma1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 263
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)..
• Protein Sequence: MFRNQYDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSELAAHQKKILHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGSKTQIPTQRYGRRPYGVGLLIAGYDDMGPHVFQTCPSANYFDCRAMSIGARSQSARTYLERHMSEFMQCNLDELVKHGLRALRETLPAEQDLTTKNVSIGIVGKDLEFTIYDDDDVSPFLDGLEERPQRKAQPSQAADEPAEKADEPMEH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MFRNQYDN -------CCCCCCCC	6.85	2335242
14	Phosphorylation	DNDVTVWSPQGRIHQ CCCCEEECCCCCCHH	11.74	23984901
54	Phosphorylation	VALKRAQSELAAHQK HHHHHHHHHHHHHHH	33.33	23984901
110	Phosphorylation	LPVSRLVSLIGSKTQ CCHHHHHHHHCCCCC	20.89	23984901
110	O-linked_Glycosylation	LPVSRLVSLIGSKTQ CCHHHHHHHHCCCCC	20.89	-
114	Phosphorylation	RLVSLIGSKTQIPTQ HHHHHHCCCCCCCCC	26.07	23984901
115	Ubiquitination	LVSLIGSKTQIPTQR HHHHHCCCCCCCCCC	38.96	-
177	Phosphorylation	TYLERHMSEFMQCNL HHHHHHHHHHHCCCH	22.89	30181290
247	Phosphorylation	PQRKAQPSQAADEPA CCHHCCCCHHCCCHH	21.99	29779826

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PSA1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PSA1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PSA1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of PSA1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"The NH2-terminal residues of rat liver proteasome (multicatalyticproteinase complex) subunits, C2, C3 and C8, are N alpha-acetylated.";
Tokunaga F., Aruga R., Iwanaga S., Tanaka K., Ichihara A., Takao T.,Shimonishi Y.;
FEBS Lett. 263:373-375(1990).
Cited for: PROTEIN SEQUENCE OF 1-30.
PubMed: 2335242