PRS6B_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PRS6B_RAT
• UniProt AC: Q63570
• Protein Name: 26S proteasome regulatory subunit 6B
• Gene Name: Psmc4
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 418
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC4 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides..
• Protein Sequence: MEEIGILVEKIQDEIPALSVSRPQTGLSFLGPEPEDLEDLYSRYKKLQQELEFLEVQEEYIKDEQKNLKKEFLHAQEEVKRIQSIPLVIGQFLEAVDQNTAIVGSTTGSNYYVRILSTIDRELLKPNASVALHKHSNALVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAVRENRYIVLAKDFEKAYKTVIKKDEQEHEFYK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEEIGILV -------CCCCCHHH	10.60	-
19	Phosphorylation	QDEIPALSVSRPQTG HHHCCCCCCCCCCCC	21.83	28432305
21	Phosphorylation	EIPALSVSRPQTGLS HCCCCCCCCCCCCCC	34.56	28432305
25	Phosphorylation	LSVSRPQTGLSFLGP CCCCCCCCCCCCCCC	42.65	23984901
28	Phosphorylation	SRPQTGLSFLGPEPE CCCCCCCCCCCCCCC	21.55	28432305
238	Acetylation	VGSEFVQKYLGEGPR HCHHHHHHHHCCCCH	36.82	22902405
238	Ubiquitination	VGSEFVQKYLGEGPR HCHHHHHHHHCCCCH	36.82	-
330	Acetylation	RPGRLDRKIEFPLPD CCCCCCCCEECCCCC	46.37	22902405
397	Acetylation	NRYIVLAKDFEKAYK CEEEEEECCHHHHHH	59.81	22902405
401	Acetylation	VLAKDFEKAYKTVIK EEECCHHHHHHHHHC	57.94	22902405
404	Acetylation	KDFEKAYKTVIKKDE CCHHHHHHHHHCHHH	40.97	22902405
408	Acetylation	KAYKTVIKKDEQEHE HHHHHHHCHHHHHCC	50.24	22902405
409	Succinylation	AYKTVIKKDEQEHEF HHHHHHCHHHHHCCC	56.21	26843850

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PRS6B_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PRS6B_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PRS6B_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of PRS6B_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.