PRRT4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PRRT4_HUMAN
• UniProt AC: C9JH25
• Protein Name: Proline-rich transmembrane protein 4
• Gene Name: PRRT4
• Organism: Homo sapiens (Human).
• Sequence Length: 899
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Sequence: MARHGCLGLGLFCCVLFAATVGPQPTPSIPGAPATTLTPVPQSEASMLSLNLGLNFKFHLRGPAAVWGSPVTETQPLSLGPGQEPGEEVASGLRTDPLWELLVGSSGNSLTEWGSTEGGSKPRASSLLPESTSRRSGPSDGPTAPYQPRRSTVTWDTALMVTALPSSAPRPHQSELELKFDMALRAGAAPTLGHRTLPLLPSLRASLAEIAGRLGPFGFFGTTLSPLRNFSGLSPPGETTSTSSASGVSGSLGFLGTTLSLPPYSLERKLSSPSPLDPAASLSFASIATTSLDPTVPISGPDDLSPPASLGNPSGQPECGPGSCSVGELPEREGQPPEAPRPLFFLTLEADWAEARARWGLAWEAHVYGVGALFGLVALLALLALALLPWRCPPGAPCLALLDLLLLSAGTTRAFPLFYDAYGHRDRLPALAWLLLQDLPLPCLAAGLGLACLLLARPRPPRCPTGLAALLLLGLGLAAAAALGSAAHRPLRPLRLASRGLHAFLAAFLSGLLLALSCWGGRRRRAGAPLGGSGFKGATPLPQGRSPFAPRESWRRAARTAPVAGTFGLLSGALQGYEVLHALGYGGQSGLEGPWPWWAFQLGLRLGEVGVALPLALLGLYPALCSPRVPPRCWAKLFRLSPGHAAPLLPGGWVTGPPDKEPLGSAIARGDAELLQLCALAGPGPDLLLQGGGCRGFEGAAANPAPSPASSPCSDYTVDFRPPSPINLRRSIEEALCSEALLAPGLFQGPAFEDALPGLGLYRTASLGTGGRASERSGEASGPAAPPELPSPGAWPAGSSVSSGSFCGLSRDSSSMLLCSSPDRPPRCPLVCVLSPPRPSGSSPSLPASGSYQALSPPSRDSPEPASELQAEEALLQEQFLDACRQIDELSVGSDTIDL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
78	O-linked_Glycosylation	VTETQPLSLGPGQEP CCCCCCCCCCCCCCC	37.65	OGP
106	Phosphorylation	WELLVGSSGNSLTEW HHHHCCCCCCCCCCC	35.74	30576142
111	Phosphorylation	GSSGNSLTEWGSTEG CCCCCCCCCCCCCCC	29.52	30576142
125	Phosphorylation	GGSKPRASSLLPEST CCCCCCHHHCCCCCC	23.85	24505115
126	Phosphorylation	GSKPRASSLLPESTS CCCCCHHHCCCCCCC	32.70	24505115
132	Phosphorylation	SSLLPESTSRRSGPS HHCCCCCCCCCCCCC	25.29	22210691
133	Phosphorylation	SLLPESTSRRSGPSD HCCCCCCCCCCCCCC	34.67	24505115
139	O-linked_Glycosylation	TSRRSGPSDGPTAPY CCCCCCCCCCCCCCC	59.74	55824499
143	Phosphorylation	SGPSDGPTAPYQPRR CCCCCCCCCCCCCCC	45.88	22210691
143	O-linked_Glycosylation	SGPSDGPTAPYQPRR CCCCCCCCCCCCCCC	45.88	55824503
146	Phosphorylation	SDGPTAPYQPRRSTV CCCCCCCCCCCCCCC	28.78	22210691
152	Phosphorylation	PYQPRRSTVTWDTAL CCCCCCCCCCCCCHH	21.83	17929957
157	Phosphorylation	RSTVTWDTALMVTAL CCCCCCCCHHHHEEC	17.16	17929957
166	O-linked_Glycosylation	LMVTALPSSAPRPHQ HHHEECCCCCCCCCC	39.73	OGP
191	Phosphorylation	LRAGAAPTLGHRTLP HHCCCCCCCCCCHHH	40.42	22210691
196	O-linked_Glycosylation	APTLGHRTLPLLPSL CCCCCCCHHHCHHHH	27.36	OGP
202	Phosphorylation	RTLPLLPSLRASLAE CHHHCHHHHHHHHHH	30.38	24719451
206	O-linked_Glycosylation	LLPSLRASLAEIAGR CHHHHHHHHHHHHHH	22.98	55830639
225	Phosphorylation	GFFGTTLSPLRNFSG CCCCCCCCCCCCCCC	21.57	24719451
309	O-linked_Glycosylation	DDLSPPASLGNPSGQ CCCCCCHHHCCCCCC	42.45	OGP
314	O-linked_Glycosylation	PASLGNPSGQPECGP CHHHCCCCCCCCCCC	54.80	OGP
533	Phosphorylation	AGAPLGGSGFKGATP CCCCCCCCCCCCCCC	38.98	28464451
536	Ubiquitination	PLGGSGFKGATPLPQ CCCCCCCCCCCCCCC	51.68	21906983
641	Phosphorylation	WAKLFRLSPGHAAPL HHHHHCCCCCCCCCC	25.28	26471730
655	Phosphorylation	LLPGGWVTGPPDKEP CCCCCEECCCCCCCC	37.15	25002506
660	Ubiquitination	WVTGPPDKEPLGSAI EECCCCCCCCCCHHH	67.99	2190698
665	Phosphorylation	PDKEPLGSAIARGDA CCCCCCCHHHHHCCH	24.96	25002506
707	Phosphorylation	AAANPAPSPASSPCS CCCCCCCCCCCCCCC	34.89	27732954
710	Phosphorylation	NPAPSPASSPCSDYT CCCCCCCCCCCCCCC	37.89	27732954
711	Phosphorylation	PAPSPASSPCSDYTV CCCCCCCCCCCCCCC	31.84	27732954
714	Phosphorylation	SPASSPCSDYTVDFR CCCCCCCCCCCCCCC	36.72	27732954
716	Phosphorylation	ASSPCSDYTVDFRPP CCCCCCCCCCCCCCC	7.74	27732954
717	Phosphorylation	SSPCSDYTVDFRPPS CCCCCCCCCCCCCCC	20.70	27732954
724	Phosphorylation	TVDFRPPSPINLRRS CCCCCCCCCCCCCHH	40.89	26074081
762	Phosphorylation	ALPGLGLYRTASLGT CCCCCCEECEECCCC	12.24	-
764	Phosphorylation	PGLGLYRTASLGTGG CCCCEECEECCCCCC	13.67	30177828
766	Phosphorylation	LGLYRTASLGTGGRA CCEECEECCCCCCCC	27.07	29900121
769	Phosphorylation	YRTASLGTGGRASER ECEECCCCCCCCCCC	41.58	27732954
814	Phosphorylation	CGLSRDSSSMLLCSS CCCCCCCCCCEEECC	24.85	25332170
820	Phosphorylation	SSSMLLCSSPDRPPR CCCCEEECCCCCCCC	44.89	26471730
821	Phosphorylation	SSMLLCSSPDRPPRC CCCEEECCCCCCCCC	29.80	26471730
835	Phosphorylation	CPLVCVLSPPRPSGS CCEEEEECCCCCCCC	16.68	24719451
891	Phosphorylation	CRQIDELSVGSDTID HHHHHHCCCCCCCCC	23.53	22115753
894	Phosphorylation	IDELSVGSDTIDL-- HHHCCCCCCCCCC--	29.44	29449344
896	Phosphorylation	ELSVGSDTIDL---- HCCCCCCCCCC----	20.35	29449344

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PRRT4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PRRT4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PRRT4_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of PRRT4_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.