dbPTM

PRPS1_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PRPS1_RAT
UniProt AC	P60892
Protein Name	Ribose-phosphate pyrophosphokinase 1
Gene Name	Prps1
Organism	Rattus norvegicus (Rat).
Sequence Length	318
Subcellular Localization
Protein Description	Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis..
Protein Sequence	MPNIKIFSGSSHQDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDNLMELLIMINACKIASASRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIRENISEWRNCTIVSPDAGGAKRVTSIADRLNVDFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGATRVYAILTHGIFSGPAISRINNACFEAVVVTNTIPQEDKMKHCSKIQVIDISMILAEAIRRTHNGESVSYLFSHVPL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MPNIKIFSGSSHQDL CCCEEEECCCCCHHH	41.04	27097102
10	Phosphorylation	NIKIFSGSSHQDLSQ CEEEECCCCCHHHHH	24.37	27097102
11	Phosphorylation	IKIFSGSSHQDLSQK EEEECCCCCHHHHHH	28.79	27097102
18	Ubiquitination	SHQDLSQKIADRLGL CCHHHHHHHHHHHCH	36.16	-
36	Phosphorylation	KVVTKKFSNQETCVE CHHHEECCCCCEEEE	46.62	16641100
47	Phosphorylation	TCVEIGESVRGEDVY EEEECCCCCCCCCEE	16.35	16641100
194	Acetylation	VDFALIHKERKKANE CCEEHHCHHHHHCCC	52.82	22902405
212	Ubiquitination	MVLVGDVKDRVAILV EEEECCHHHCEEEEE	44.55	-
238	Phosphorylation	HAADKLLSAGATRVY HHHHHHHHCCCCEEE	34.78	23984901
242	Phosphorylation	KLLSAGATRVYAILT HHHHCCCCEEEHHHH	21.54	23984901

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PRPS1_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PRPS1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PRPS1_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
XIAP_RAT	Xiap	physical	22792159

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PRPS1_RAT

Related Literatures of Post-Translational Modification