dbPTM

PROX2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PROX2_MOUSE
UniProt AC	Q8BII1
Protein Name	Prospero homeobox protein 2
Gene Name	Prox2
Organism	Mus musculus (Mouse).
Sequence Length	593
Subcellular Localization	Nucleus .
Protein Description	Transcription regulator. Does not seem to be essential for embryonic development and postnatal survival..
Protein Sequence	MDPPAAVLLPPQSRTCTHLAEETCMDQERSPATAEAGRDSFPSGQLPSSSLTEADWFWDEHIQAKRARVETIVRGMCLSPSSSVSGRARESLRCPEKGRERKRKQSLPMHQGPLKSSPAWERGPKKGGTRVKEQLHLLKQQLRHLQEHVLQATEPRAPAQSPGGTEPRSSPRARPRNSCSSGAWTVENEPHQSSSKDLCGAVKPGAAEVLQYSEEPMLCPSGPRALVETLRKELSRAVSQAVDSVLQQVLFDPQRHLTQQERSCQGLASEGRNQPSPPGRSAYKDPLALATLPRKIQPQAGVPLGNSTLARPLDSPMCPVSPRGVPRSYQSPLPNCPLTNVPSHTWENQMLRQLLGRGPDGQWSGSPPQDAAFQSHTSPESAQQPWGLSQQQLPLSLTPVHLESRPLPPPVKMEQGVLRGVADSLPFSSIHIQEGLSPGHLKKAKLMFFFTRYPSSSLLKAYFPDVQFNRCITSQMIKWFSNFREFYYIQMEKYARQALSDGITNAQALAVLRDSELFRVLNTHYNKGNDFEVPDCFLEIAALTLKEFFRAVLAGKDSDPSWKKPIYKVISKLDSDVPEMLKSPSFLPGLFPS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
457	Phosphorylation	FTRYPSSSLLKAYFP ECCCCCHHHHHHHCC	41.90	24453211
571	Phosphorylation	KPIYKVISKLDSDVP CCHHHHHHHHCCCHH	30.10	25619855

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PROX2_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PROX2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PROX2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of PROX2_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PROX2_MOUSE

Related Literatures of Post-Translational Modification