PROM2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PROM2_HUMAN
• UniProt AC: Q8N271
• Protein Name: Prominin-2
• Gene Name: PROM2
• Organism: Homo sapiens (Human).
• Sequence Length: 834
• Subcellular Localization: Apical cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Cell projection, microvillus membrane; Multi-pass membrane protein. Cell projection, cilium membrane; Multi-pass membrane protein. Colocalizes
• Protein Sequence: MKHTLALLAPLLGLGLGLALSQLAAGATDCKFLGPAEHLTFTPAARARWLAPRVRAPGLLDSLYGTVRRFLSVVQLNPFPSELVKALLNELASVKVNEVVRYEAGYVVCAVIAGLYLLLVPTAGLCFCCCRCHRRCGGRVKTEHKALACERAALMVFLLLTTLLLLIGVVCAFVTNQRTHEQMGPSIEAMPETLLSLWGLVSDVPQELQAVAQQFSLPQEQVSEELDGVGVSIGSAIHTQLRSSVYPLLAAVGSLGQVLQVSVHHLQTLNATVVELQAGQQDLEPAIREHRDRLLELLQEARCQGDCAGALSWARTLELGADFSQVPSVDHVLHQLKGVPEANFSSMVQEENSTFNALPALAAMQTSSVVQELKKAVAQQPEGVRTLAEGFPGLEAASRWAQALQEVEESSRPYLQEVQRYETYRWIVGCVLCSVVLFVVLCNLLGLNLGIWGLSARDDPSHPEAKGEAGARFLMAGVGLSFLFAAPLILLVFATFLVGGNVQTLVCQSWENGELFEFADTPGNLPPSMNLSQLLGLRKNISIHQAYQQCKEGAALWTVLQLNDSYDLEEHLDINQYTNKLRQELQSLKVDTQSLDLLSSAARRDLEALQSSGLQRIHYPDFLVQIQRPVVKTSMEQLAQELQGLAQAQDNSVLGQRLQEEAQGLRNLHQEKVVPQQSLVAKLNLSVRALESSAPNLQLETSDVLANVTYLKGELPAWAARILRNVSECFLAREMGYFSQYVAWVREEVTQRIATCQPLSGALDNSRVILCDMMADPWNAFWFCLAWCTFFLIPSIIFAVKTSKYFRPIRKRLSSTSSEETQLFHIPRVTSLKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
40	Phosphorylation	LGPAEHLTFTPAARA CCCHHHHCCCHHHHH	27.63	-
42	Phosphorylation	PAEHLTFTPAARARW CHHHHCCCHHHHHHH	13.54	-
72	Phosphorylation	GTVRRFLSVVQLNPF HHHHHHHHHHCCCCC	19.96	24719451
81	Phosphorylation	VQLNPFPSELVKALL HCCCCCCHHHHHHHH	43.89	24719451
102	Phosphorylation	KVNEVVRYEAGYVVC CHHHHHHHCCHHHHH	9.87	25693802
106	Phosphorylation	VVRYEAGYVVCAVIA HHHHCCHHHHHHHHH	9.21	25693802
116	Phosphorylation	CAVIAGLYLLLVPTA HHHHHHHHHHHHCCC	8.39	25693802
270	N-linked_Glycosylation	VHHLQTLNATVVELQ HHHHHHCCCEEEEHH	36.63	UniProtKB CARBOHYD
686	Phosphorylation	LVAKLNLSVRALESS HHHHHCHHHHHHHCC	14.42	23403867
727	Phosphorylation	ARILRNVSECFLARE HHHHHHHHHHHHHHH	32.00	19690332
802	Phosphorylation	SIIFAVKTSKYFRPI HHHHHHHCCCCCHHH	24.69	-
803	Phosphorylation	IIFAVKTSKYFRPIR HHHHHHCCCCCHHHH	21.46	-
805	Phosphorylation	FAVKTSKYFRPIRKR HHHHCCCCCHHHHHH	12.46	-
814	Phosphorylation	RPIRKRLSSTSSEET HHHHHHHCCCCCCCH	35.29	22617229
815	Phosphorylation	PIRKRLSSTSSEETQ HHHHHHCCCCCCCHH	36.58	27273156
816	Phosphorylation	IRKRLSSTSSEETQL HHHHHCCCCCCCHHC	32.66	27273156
817	Phosphorylation	RKRLSSTSSEETQLF HHHHCCCCCCCHHCC	37.39	27273156
818	Phosphorylation	KRLSSTSSEETQLFH HHHCCCCCCCHHCCC	39.27	28355574
821	Phosphorylation	SSTSSEETQLFHIPR CCCCCCCHHCCCCCC	26.90	27794612
831	Phosphorylation	FHIPRVTSLKL---- CCCCCCCCCCC----	22.20	20639409

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PROM2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PROM2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PROM2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of PROM2_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.