PRL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PRL_HUMAN
• UniProt AC: P01236
• Protein Name: Prolactin
• Gene Name: PRL
• Organism: Homo sapiens (Human).
• Sequence Length: 227
• Subcellular Localization: Secreted.
• Protein Description: Prolactin acts primarily on the mammary gland by promoting lactation..
• Protein Sequence: MNIKGSPWKGSLLLLLVSNLLLCQSVAPLPICPGGAARCQVTLRDLFDRAVVLSHYIHNLSSEMFSEFDKRYTHGRGFITKAINSCHTSSLATPEDKEQAQQMNQKDFLSLIVSILRSWNEPLYHLVTEVRGMQEAPEAILSKAVEIEEQTKRLLEGMELIVSQVHPETKENEIYPVWSGLPSLQMADEESRLSAYYNLLHCLRRDSHKIDNYLKLLKCRIIHNNNC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
54	Phosphorylation	FDRAVVLSHYIHNLS HHHHHHHHHHHHHHC	11.57	-
56	Phosphorylation	RAVVLSHYIHNLSSE HHHHHHHHHHHHCHH	10.66	22210691
59	N-linked_Glycosylation	VLSHYIHNLSSEMFS HHHHHHHHHCHHHHH	31.87	UniProtKB CARBOHYD
62	Phosphorylation	HYIHNLSSEMFSEFD HHHHHHCHHHHHHHH	35.93	-
66	Phosphorylation	NLSSEMFSEFDKRYT HHCHHHHHHHHHHHC	35.72	22210691
118	Phosphorylation	LIVSILRSWNEPLYH HHHHHHHHCCCCHHH	30.70	-
163	Phosphorylation	EGMELIVSQVHPETK HHHHHHHHCCCCCCC	21.35	15687336
179	Phosphorylation	NEIYPVWSGLPSLQM CCEECCCCCCCCCCC	30.59	16840547
194	Phosphorylation	ADEESRLSAYYNLLH CCHHHHHHHHHHHHH	17.08	15687336
207	Phosphorylation	LHCLRRDSHKIDNYL HHHHHHCCCCHHHHH	25.52	19555049

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
207	S	Phosphorylation	Kinase	PAK2	Q13177	PhosphoELM
207	S	Phosphorylation	Kinase	PAK2	Q64303	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PRL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PRL_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PPIB_HUMAN	PPIB	physical	10935542
DQB2_HUMAN	HLA-DQB2	physical	26186194
DQB2_HUMAN	HLA-DQB2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.