dbPTM

PRIC1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PRIC1_MOUSE
UniProt AC	Q3U5C7
Protein Name	Prickle-like protein 1
Gene Name	Prickle1
Organism	Mus musculus (Mouse).
Sequence Length	832
Subcellular Localization	Nucleus membrane. Cytoplasm, cytosol. A smaller amount is detected in the cytosol..
Protein Description	Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure (By similarity). Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor (By similarity)..
Protein Sequence	MPLEMEPKMSKLVFGCQRSSTSDDDSGCALEEYAWVPPGLRPEQIQLYFACLPEEKVPYVNSPGEKHRIKQLLYQLPPHDNEVRYCQSLSEEEKKELQVFSAQRKKEALGRGTIKLLSRAVMHAVCEQCGLQMNGGEVAVFASRAGPGVCWHPSCFVCFTCNELLVDLIYFYQDGKIHCGRHHAELLKPRCSACDEIIFADECTEAEGRHWHMKHFCCLECETVLGGQRYIMKDGRPFCCGCFESLYAEYCETCGEHIGVDHAQMTYDGQHWHATEACFSCAQCKASLLGCPFLPKQGQIYCSKTCSLGEDIHASDSSDSAFQSARSRDSRRSVRMGRSSRSADQCRQSLLLSPALNYKFPGLSGNADDTLSRKLDDVSLASRQGAGFANEEFWKARVEQEASEDPEEWAEHEDYMTQLLLKFGDKNLFQQQSSEVDPRASEHWIPDNMVTNKPEVKPNHQGLASKKYQSDMYWAQSQDGLGDSAYGSHPGPASSRRLQELDLDHGAAGYTHDQSQWYEDSLECLSDLKPEQSIRDSMDSLALSNITGASVDGESKPRPSLYSLQNFEEIEAEDCEKMSNMGTLNSSMLHRSAESLQSLNSGLCPEKILPEEKPAHLPVLRRSKSQSRPQQVKFSDDVIDNGSYDIEIRQPPMSERTRRRAYHFEERGSRPHHHRHRRSRKSRSDNALNLVTERKYSAKDRLRLYTPDNYEKFIQNKSARELQAYMQNANLYSQYAHATSDYALQNPGMNRFLGLCGEDDDSWCSSSTSSSDSEEEGYFLGQPIPQPRPQRFTYYTDDLSSPASALPTPQFTQRTTKSKKKKGHKGKNCIIS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
101	Phosphorylation	KKELQVFSAQRKKEA HHHHHHHHHHHHHHH	25.33	26824392
305	Phosphorylation	GQIYCSKTCSLGEDI CEEEECCCCCCCCCC	7.34	25293948
307	Phosphorylation	IYCSKTCSLGEDIHA EEECCCCCCCCCCCC	44.64	25293948
315	Phosphorylation	LGEDIHASDSSDSAF CCCCCCCCCCCCHHH	24.70	22817900
317	Phosphorylation	EDIHASDSSDSAFQS CCCCCCCCCCHHHHH	33.28	22817900
318	Phosphorylation	DIHASDSSDSAFQSA CCCCCCCCCHHHHHH	40.34	19060867
320	Phosphorylation	HASDSSDSAFQSARS CCCCCCCHHHHHHHH	32.69	24759943
324	Phosphorylation	SSDSAFQSARSRDSR CCCHHHHHHHHHHHH	21.13	25293948
349	Phosphorylation	SADQCRQSLLLSPAL CHHHHHHHHHHCHHH	11.13	23984901
353	Phosphorylation	CRQSLLLSPALNYKF HHHHHHHCHHHCCCC	14.22	23984901
359	Ubiquitination	LSPALNYKFPGLSGN HCHHHCCCCCCCCCC	43.97	-
395	Ubiquitination	FANEEFWKARVEQEA CCCHHHHHHHHHHHH	31.47	-
415	Phosphorylation	EWAEHEDYMTQLLLK HHHHCHHHHHHHHHH	10.08	29899451
433	Phosphorylation	KNLFQQQSSEVDPRA CCHHHCCCCCCCCCH	24.91	29899451
477	Phosphorylation	SDMYWAQSQDGLGDS CCCCEEECCCCCCCC	23.61	29899451
592	Phosphorylation	NSSMLHRSAESLQSL CHHHHHHCHHHHHHH	26.16	25521595
595	Phosphorylation	MLHRSAESLQSLNSG HHHHCHHHHHHHHCC	31.27	25521595
598	Phosphorylation	RSAESLQSLNSGLCP HCHHHHHHHHCCCCH	34.51	25159016
601	Phosphorylation	ESLQSLNSGLCPEKI HHHHHHHCCCCHHHH	38.13	25293948
625	Phosphorylation	PVLRRSKSQSRPQQV CHHCCCCCCCCCCEE	34.33	25266776
627	Phosphorylation	LRRSKSQSRPQQVKF HCCCCCCCCCCEECC	53.68	23684622
654	Phosphorylation	EIRQPPMSERTRRRA EECCCCCCHHHHHHH	29.69	-
682	Phosphorylation	RHRRSRKSRSDNALN HHHHHHHHHCCCHHH	35.59	27742792
684	Phosphorylation	RRSRKSRSDNALNLV HHHHHHHCCCHHHHH	42.16	25521595
692	Phosphorylation	DNALNLVTERKYSAK CCHHHHHHHCCCCHH	32.99	24899341
710	Phosphorylation	RLYTPDNYEKFIQNK EEECCCHHHHHHHCC	28.07	29514104
800	Phosphorylation	TYYTDDLSSPASALP EEEECCCCCCHHHCC	41.07	29899451
829	Methylation	KGHKGKNCIIS---- CCCCCCCCCCC----	3.13	-
829	Farnesylation	KGHKGKNCIIS---- CCCCCCCCCCC----	3.13	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PRIC1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PRIC1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PRIC1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
DVL1_MOUSE	Dvl1	genetic	19788910

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PRIC1_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-682, AND MASSSPECTROMETRY.	19367708 [Abstract]