PREP_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PREP_MOUSE
• UniProt AC: Q8K411
• Protein Name: Presequence protease, mitochondrial {ECO:0000305}
• Gene Name: Pitrm1 {ECO:0000312|MGI:MGI:1916867}
• Organism: Mus musculus (Mouse).
• Sequence Length: 1036
• Subcellular Localization: Mitochondrion matrix .
• Protein Description: Metalloendopeptidase of the mitochondrial matrix that functions in peptide cleavage and degradation rather than in protein processing. Has an ATP-independent activity. Specifically cleaves peptides in the range of 5 to 65 residues. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference. Degrades the transit peptides of mitochondrial proteins after their cleavage. Also degrades other unstructured peptides. It is also able to degrade amyloid-beta protein 40, one of the peptides produced by APP processing, when it accumulates in mitochondrion. It is a highly efficient protease, at least toward amyloid-beta protein 40. Cleaves that peptide at a specific position and is probably not processive, releasing digested peptides intermediates that can be further cleaved subsequently..
• Protein Sequence: MWRFSGRRGLCAVQRLSCGRVHHRVWREKSDQACERALQYKVGEKIHGFTVNQVTPVPELFLTAVKLSHDNTGARYLHLAREDKNNLFSVQFRTTPMDSTGVPHVLEHTVLCGSQKYPCRDPFFKMLNRSLSTFMNAMTASDYTIYPFSTQNPKDFQNLLSVYLDATFFPCLRELDFWQEGWRLEHENPRDPQTPLIFKGVVFNEMKGAFTDNERIFSQHLQNKLLPDHTYSVVSGGDPLCIPELTWEQLKQFHATHYHPSNARFFTYGNFQLEGHLKQIHEEALSKFQRLEQSTAVPAQPHWDKPREFHITCGPDSLATETAKQTTVSVSFLLPDITDTFEAFTLSLLSSLLIAGPNSPFYKALIESGLGTDFSPDVGYNGYTREAYFSVGLQGIAEKDVKTVRELVDRTIEEVIEKGFEDDRIEALLHKIEIQTKHQSASFGLTLTSYIASCWNHDGDPVELLQIGSQLTRFRKCLKENPKFLQEKVEQYFKNNQHKLTLSMKPDDKYYEKQTQMETEKLEQKVNSLSPADKQQIYEKGLELQTQQSKHQDASCLPALKVSDIEPSMPFTKLDIGLAAGDIPVQYCPQPTNGMVYFRAFSSLNTLPEDLRPIVPLFCSVLTKLGCGILNYREQAQQIELKTGGMSVTPHVLPDDSQLDTYEQGVLFSSLCLERNLPDMMHLWSEIFNNPCFEEEEHFKVLVKMTAQELSNGISDSGHLYAALRASKTLTPSGDLQETFSGMDQVKVMKRIAEMTDIKPILRKLPRIKKYLLNCDNMRCSVNATPQQMPQAEKEVENFLRNVGRSKKERKPVRPHIVEKPTPSGPSGAAHVSGSQIVRKLVTDPTFKPCQMKTHFVLPFPVNYIGECVRTVPYADPDHASLKILARLMTAKFLHTEIREKGGAYGGGAKLTHSGIFTLYSYRDPNSIETLQSFGKAVDWAKSGKFTQQDIDEAKLSVFSTVDSPVAPSDKGMDHFLYGLSDEMKQAYREQLFAVNHDKLTSVSHKYLGIGKSTHGLAILGPENSKIAKDPSWIIK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
41	Succinylation	CERALQYKVGEKIHG HHHHHHHHHCCEECC	30.70	23806337
41	Acetylation	CERALQYKVGEKIHG HHHHHHHHHCCEECC	30.70	23806337
84	Acetylation	LHLAREDKNNLFSVQ EEEEECCCCCCEEEE	42.87	23236377
287	Acetylation	IHEEALSKFQRLEQS HHHHHHHHHHHHHHC	46.49	23954790
305	Acetylation	PAQPHWDKPREFHIT CCCCCCCCCCEEEEE	40.56	23201123
312	Phosphorylation	KPREFHITCGPDSLA CCCEEEEEECCCCCC	11.66	22817900
322	Phosphorylation	PDSLATETAKQTTVS CCCCCCCCCCCCEEE	34.50	22817900
418	Acetylation	TIEEVIEKGFEDDRI HHHHHHHCCCCCHHH	58.75	23954790
476	Acetylation	SQLTRFRKCLKENPK HHHHHHHHHHHHCHH	41.00	7721377
479	Acetylation	TRFRKCLKENPKFLQ HHHHHHHHHCHHHHH	65.99	7721387
483	Acetylation	KCLKENPKFLQEKVE HHHHHCHHHHHHHHH	71.00	22826441
488	Acetylation	NPKFLQEKVEQYFKN CHHHHHHHHHHHHHH	37.80	22826441
505	Acetylation	HKLTLSMKPDDKYYE CEEEEEECCCHHHHH	41.75	23201123
509	Acetylation	LSMKPDDKYYEKQTQ EEECCCHHHHHHHHH	58.05	23954790
521	Acetylation	QTQMETEKLEQKVNS HHHHHHHHHHHHHHC	65.82	23954790
528	Phosphorylation	KLEQKVNSLSPADKQ HHHHHHHCCCHHHHH	32.96	28066266
530	Phosphorylation	EQKVNSLSPADKQQI HHHHHCCCHHHHHHH	20.19	28066266
550	Acetylation	ELQTQQSKHQDASCL HHHHHHCCCCCCCCC	40.73	23806337
556	S-nitrosylation	SKHQDASCLPALKVS CCCCCCCCCCCEEHH	5.90	21278135
556	S-nitrosocysteine	SKHQDASCLPALKVS CCCCCCCCCCCEEHH	5.90	-
627	S-nitrosylation	SVLTKLGCGILNYRE HHHHHHCCCCCCHHH	4.43	21278135
627	S-nitrosocysteine	SVLTKLGCGILNYRE HHHHHHCCCCCCHHH	4.43	-
747	Succinylation	FSGMDQVKVMKRIAE HCCHHHHHHHHHHHH	30.86	23954790
747	Acetylation	FSGMDQVKVMKRIAE HCCHHHHHHHHHHHH	30.86	23236377
759	Succinylation	IAEMTDIKPILRKLP HHHHCCCHHHHHHCH	28.90	26388266
759	Acetylation	IAEMTDIKPILRKLP HHHHCCCHHHHHHCH	28.90	23806337
770	Succinylation	RKLPRIKKYLLNCDN HHCHHHHHHHHCCCC	38.47	23806337
770	Succinylation	RKLPRIKKYLLNCDN HHCHHHHHHHHCCCC	38.47	-
770	Malonylation	RKLPRIKKYLLNCDN HHCHHHHHHHHCCCC	38.47	26320211
770	Acetylation	RKLPRIKKYLLNCDN HHCHHHHHHHHCCCC	38.47	23576753
771	Phosphorylation	KLPRIKKYLLNCDNM HCHHHHHHHHCCCCC	16.06	25195567
780	S-nitrosylation	LNCDNMRCSVNATPQ HCCCCCCEECCCCHH	3.56	21278135
780	S-nitrosocysteine	LNCDNMRCSVNATPQ HCCCCCCEECCCCHH	3.56	-
811	Acetylation	GRSKKERKPVRPHIV CCCCCCCCCCCCCEE	49.29	24062335
840	Acetylation	SGSQIVRKLVTDPTF CHHHHHHHHHCCCCC	36.09	22826441
848	Succinylation	LVTDPTFKPCQMKTH HHCCCCCCCCCCEEE	47.57	-
848	Acetylation	LVTDPTFKPCQMKTH HHCCCCCCCCCCEEE	47.57	23864654
848	Succinylation	LVTDPTFKPCQMKTH HHCCCCCCCCCCEEE	47.57	23806337
883	Succinylation	DPDHASLKILARLMT CCCHHHHHHHHHHHH	32.93	23806337
883	Acetylation	DPDHASLKILARLMT CCCHHHHHHHHHHHH	32.93	23576753
892	Acetylation	LARLMTAKFLHTEIR HHHHHHHHHHCHHHH	39.01	22826441
942	Acetylation	GKAVDWAKSGKFTQQ HHHHHHHHCCCCCHH	56.33	23806337
942	Succinylation	GKAVDWAKSGKFTQQ HHHHHHHHCCCCCHH	56.33	23806337
945	Acetylation	VDWAKSGKFTQQDID HHHHHCCCCCHHHHH	52.94	23864654
945	Succinylation	VDWAKSGKFTQQDID HHHHHCCCCCHHHHH	52.94	23806337
945	Succinylation	VDWAKSGKFTQQDID HHHHHCCCCCHHHHH	52.94	-
960	Phosphorylation	EAKLSVFSTVDSPVA HHHHEEEEEECCCCC	25.93	21743459
961	Phosphorylation	AKLSVFSTVDSPVAP HHHEEEEEECCCCCC	19.50	21743459
964	Phosphorylation	SVFSTVDSPVAPSDK EEEEEECCCCCCCCC	19.55	26745281
1001	Phosphorylation	AVNHDKLTSVSHKYL CCCHHHHHCCCCCCC	32.59	23140645
1002	Phosphorylation	VNHDKLTSVSHKYLG CCHHHHHCCCCCCCC	31.87	23140645
1004	Phosphorylation	HDKLTSVSHKYLGIG HHHHHCCCCCCCCCC	17.65	23140645
1006	Acetylation	KLTSVSHKYLGIGKS HHHCCCCCCCCCCCC	34.36	22826441
1026	Acetylation	ILGPENSKIAKDPSW EECCCCCCCCCCCCC	59.26	23806337
1026	Succinylation	ILGPENSKIAKDPSW EECCCCCCCCCCCCC	59.26	23806337
1036	Succinylation	KDPSWIIK------- CCCCCCCC-------	45.19	26388266
1036	Acetylation	KDPSWIIK------- CCCCCCCC-------	45.19	24062335

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PREP_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PREP_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PREP_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PREP_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.