| UniProt ID | PRDX3_RAT | |
|---|---|---|
| UniProt AC | Q9Z0V6 | |
| Protein Name | Thioredoxin-dependent peroxide reductase, mitochondrial | |
| Gene Name | Prdx3 | |
| Organism | Rattus norvegicus (Rat). | |
| Sequence Length | 257 | |
| Subcellular Localization | Mitochondrion . Cytoplasm . Early endosome . Localizes to early endosomes in a RPS6KC1-dependent manner. | |
| Protein Description | Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.. | |
| Protein Sequence | MAAAAGRLLWSSVARPASTIFRSISASTVLRPVASRRTCLTDMLWSACPQAKFAFSTSSSFHTPAVTQHAPHFKGTAVVNGEFKELSLDDFKGKYLVLFFYPLDFTFVCPTEIVAFSDKANEFHDVNCEVVAVSVDSHFSHLAWINTPRKNGGLGHMNITLLSDLTKQISRDYGVLLESAGIALRGLFIIDPNGVIKHLSVNDLPVGRSVEEPLRLVKAFQFVETHGEVCPANWTPESPTIKPSPTASKEYFEKVHQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 84 | Succinylation | AVVNGEFKELSLDDF EEECCEEEEEECHHC | 54.14 | - | |
| 84 | Acetylation | AVVNGEFKELSLDDF EEECCEEEEEECHHC | 54.14 | 22902405 | |
| 84 | Succinylation | AVVNGEFKELSLDDF EEECCEEEEEECHHC | 54.14 | - | |
| 92 | Acetylation | ELSLDDFKGKYLVLF EEECHHCCCCEEEEE | 62.58 | 22902405 | |
| 92 | Succinylation | ELSLDDFKGKYLVLF EEECHHCCCCEEEEE | 62.58 | - | |
| 92 | Succinylation | ELSLDDFKGKYLVLF EEECHHCCCCEEEEE | 62.58 | - | |
| 94 | Acetylation | SLDDFKGKYLVLFFY ECHHCCCCEEEEEEE | 35.68 | 26302492 | |
| 147 | Phosphorylation | SHLAWINTPRKNGGL CEEEEECCCCCCCCC | 18.48 | - | |
| 179 | O-linked_Glycosylation | DYGVLLESAGIALRG HHHHHHHHHCEEEEE | 31.59 | 27213235 | |
| 197 | Acetylation | IDPNGVIKHLSVNDL ECCCCCEEEEECCCC | 35.77 | 22902405 | |
| 200 | O-linked_Glycosylation | NGVIKHLSVNDLPVG CCCEEEEECCCCCCC | 20.70 | 27213235 | |
| 235 | Phosphorylation | EVCPANWTPESPTIK CCCCCCCCCCCCCCC | 19.58 | 23984901 | |
| 238 | Phosphorylation | PANWTPESPTIKPSP CCCCCCCCCCCCCCC | 28.66 | 23984901 | |
| 240 | Phosphorylation | NWTPESPTIKPSPTA CCCCCCCCCCCCCCC | 51.41 | 23984901 | |
| 244 | Phosphorylation | ESPTIKPSPTASKEY CCCCCCCCCCCCHHH | 29.85 | 23984901 | |
| 246 | Phosphorylation | PTIKPSPTASKEYFE CCCCCCCCCCHHHHH | 48.15 | 23984901 | |
| 248 | Phosphorylation | IKPSPTASKEYFEKV CCCCCCCCHHHHHHH | 28.62 | 23984901 | |
| 254 | Acetylation | ASKEYFEKVHQ---- CCHHHHHHHCC---- | 34.81 | 22902405 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PRDX3_RAT !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PRDX3_RAT !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PRDX3_RAT !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of PRDX3_RAT !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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