PRDX2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PRDX2_RAT
• UniProt AC: P35704
• Protein Name: Peroxiredoxin-2
• Gene Name: Prdx2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 198
• Subcellular Localization: Cytoplasm .
• Protein Description: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2)..
• Protein Sequence: MASGNAHIGKPAPDFTGTAVVDGAFKEIKLSDYRGKYVVLFFYPLDFTFVCPTEIIAFSDHAEDFRKLGCEVLGVSVDSQFTHLAWINTPRKEGGLGPLNIPLLADVTKSLSQNYGVLKNDEGIAYRGLFIIDAKGVLRQITVNDLPVGRSVDEALRLVQAFQYTDEHGEVCPAGWKPGSDTIKPNVDDSKEYFSKHN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MASGNAHIG ------CCCCCCCCC	26.58	-
29	Acetylation	DGAFKEIKLSDYRGK ECCEEEEECHHCCCC	42.92	22902405
92	Succinylation	AWINTPRKEGGLGPL EEECCCCCCCCCCCC	63.01	26843850
110	Phosphorylation	LLADVTKSLSQNYGV HHHHHHHHHHHHCCE	24.72	27097102
112	Phosphorylation	ADVTKSLSQNYGVLK HHHHHHHHHHCCEEE	24.38	27097102
119	Acetylation	SQNYGVLKNDEGIAY HHHCCEEECCCCCEE	61.00	22902405
151	Phosphorylation	NDLPVGRSVDEALRL CCCCCCCCHHHHHHH	28.17	26022182
182	Phosphorylation	GWKPGSDTIKPNVDD CCCCCCCCCCCCCCC	32.37	-
191	Acetylation	KPNVDDSKEYFSKHN CCCCCCHHHHHHHCC	64.53	22902405
196	Acetylation	DSKEYFSKHN----- CHHHHHHHCC-----	36.95	22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PRDX2_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PRDX2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PRDX2_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of PRDX2_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.