PRDX1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PRDX1_RAT
• UniProt AC: Q63716
• Protein Name: Peroxiredoxin-1
• Gene Name: Prdx1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 199
• Subcellular Localization: Cytoplasm .
• Protein Description: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (By similarity). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity)..
• Protein Sequence: MSSGNAKIGHPAPSFKATAVMPDGQFKDISLSDYKGKYVVFFFYPLDFTFVCPTEIIAFSDRAEEFKKLNCQVIGASVDSHFCHLAWINTPKKQGGLGPMNIPLVSDPKRTIAQDYGVLKADEGISFRGLFIIDDKGILRQITINDLPVGRSVDEILRLVQAFQFTDKHGEVCPAGWKPGSDTIKPDVNKSKEYFSKQK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSSGNAKIG ------CCCCCCCCC	47.13	-
7	Acetylation	-MSSGNAKIGHPAPS -CCCCCCCCCCCCCC	53.90	-
14	Phosphorylation	KIGHPAPSFKATAVM CCCCCCCCCEEEEEC	41.29	29779826
16	Acetylation	GHPAPSFKATAVMPD CCCCCCCEEEEECCC	49.52	22902405
18	Phosphorylation	PAPSFKATAVMPDGQ CCCCCEEEEECCCCC	22.00	16641100
27	Acetylation	VMPDGQFKDISLSDY ECCCCCEEEEECHHC	46.38	22902405
30	Phosphorylation	DGQFKDISLSDYKGK CCCEEEEECHHCCCC	31.77	28432305
32	Phosphorylation	QFKDISLSDYKGKYV CEEEEECHHCCCCEE	31.91	29779826
34	Phosphorylation	KDISLSDYKGKYVVF EEEECHHCCCCEEEE	20.47	16641100
35	Succinylation	DISLSDYKGKYVVFF EEECHHCCCCEEEEE	54.65	-
35	Ubiquitination	DISLSDYKGKYVVFF EEECHHCCCCEEEEE	54.65	-
35	Succinylation	DISLSDYKGKYVVFF EEECHHCCCCEEEEE	54.65	-
35	Acetylation	DISLSDYKGKYVVFF EEECHHCCCCEEEEE	54.65	22902405
67	Acetylation	SDRAEEFKKLNCQVI CHHHHHHHHCCCEEE	60.68	22902405
90	Phosphorylation	CHLAWINTPKKQGGL EEEEEECCCCCCCCC	27.61	-
93	Succinylation	AWINTPKKQGGLGPM EEECCCCCCCCCCCC	56.21	26843850
109	Acetylation	IPLVSDPKRTIAQDY CCCCCCCCCCHHHHC	68.14	22902405
111	Phosphorylation	LVSDPKRTIAQDYGV CCCCCCCCHHHHCCE	27.13	29779826
116	Phosphorylation	KRTIAQDYGVLKADE CCCHHHHCCEEECCC	9.32	29779826
120	Acetylation	AQDYGVLKADEGISF HHHCCEEECCCCCCE	51.92	22902405
136	Acetylation	GLFIIDDKGILRQIT EEEEECCCCEEEEEE	44.07	22902405
152	Phosphorylation	NDLPVGRSVDEILRL CCCCCCCCHHHHHHH	28.17	30181290
181	Phosphorylation	PAGWKPGSDTIKPDV CCCCCCCCCCCCCCC	39.86	23984901
183	Phosphorylation	GWKPGSDTIKPDVNK CCCCCCCCCCCCCCH	32.37	23984901
185	Succinylation	KPGSDTIKPDVNKSK CCCCCCCCCCCCHHH	36.94	26843850
192	Acetylation	KPDVNKSKEYFSKQK CCCCCHHHHHHHCCC	59.03	165087
194	Phosphorylation	DVNKSKEYFSKQK-- CCCHHHHHHHCCC--	19.52	20178744
197	Acetylation	KSKEYFSKQK----- HHHHHHHCCC-----	52.81	22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PRDX1_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
90	T	Phosphorylation	Phosphorylated on Thr-90 during the M-phase, which leads to a decrease in enzymatic activity.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PRDX1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of PRDX1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.