PRDM8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PRDM8_HUMAN
• UniProt AC: Q9NQV8
• Protein Name: PR domain zinc finger protein 8
• Gene Name: PRDM8
• Organism: Homo sapiens (Human).
• Sequence Length: 689
• Subcellular Localization: Nucleus .
• Protein Description: Probable histone methyltransferase, preferentially acting on 'Lys-9' of histone H3 (By similarity). Involved in the control of steroidogenesis through transcriptional repression of steroidogenesis marker genes such as CYP17A1 and LHCGR (By similarity). Forms with BHLHE22 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation (By similarity). In the retina, it is required for rod bipolar and type 2 OFF-cone bipolar cell survival (By similarity)..
• Protein Sequence: MEDTGIQRGIWDGDAKAVQQCLTDIFTSVYTTCDIPENAIFGPCVLSHTSLYDSIAFIALKSTDKRTVPYIFRVDTSAANGSSEGLMWLRLVQSARDKEEQNLEAYIKNGQLFYRSLRRIAKDEELLVWYGKELTELLLLCPSRSHNKMNGSSPYTCLECSQRFQFEFPYVAHLRFRCPKRLHSADISPQDEQGGGVGTKDHGGGGGGGKDQQQQQQEAPLGPGPKFCKAGPLHHYPSPSPESSNPSAAAGGSSAKPSTDFHNLARELENSRGGSSCSPAQSLSSGSGSGGGGGHQEAELSPDGIATGGGKGKRKFPEEAAEGGGGAGLVGGRGRFVERPLPASKEDLVCTPQQYRASGSYFGLEENGRLFAPPSPETGEAKRSAFVEVKKAARAASLQEEGTADGAGVASEDQDAGGGGGSSTPAAASPVGAEKLLAPRPGGPLPSRLEGGSPARGSAFTSVPQLGSAGSTSGGGGTGAGAAGGAGGGQGAASDERKSAFSQPARSFSQLSPLVLGQKLGALEPCHPADGVGPTRLYPAAADPLAVKLQGAADLNGGCGSLPSGGGGLPKQSPFLYATAFWPKSSAAAAAAAAAAAAGPLQLQLPSALTLLPPSFTSLCLPAQNWCAKCNASFRMTSDLVYHMRSHHKKEYAMEPLVKRRREEKLKCPICNESFRERHHLSRHMTSHN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
161	Phosphorylation	PYTCLECSQRFQFEF CCCHHHCHHHEEECC	18.27	-
184	Phosphorylation	RCPKRLHSADISPQD ECCCCCCCCCCCCCC	32.03	27732954
188	Phosphorylation	RLHSADISPQDEQGG CCCCCCCCCCCCCCC	19.63	27732954
238	Phosphorylation	GPLHHYPSPSPESSN CCCCCCCCCCCCCCC	30.73	27732954
240	Phosphorylation	LHHYPSPSPESSNPS CCCCCCCCCCCCCCC	45.71	27732954
243	Phosphorylation	YPSPSPESSNPSAAA CCCCCCCCCCCCCCC	38.51	27732954
244	Phosphorylation	PSPSPESSNPSAAAG CCCCCCCCCCCCCCC	51.61	27732954
276	Phosphorylation	ENSRGGSSCSPAQSL HHCCCCCCCCCCHHC	23.14	-
278	Phosphorylation	SRGGSSCSPAQSLSS CCCCCCCCCCHHCCC	25.81	-
284	Phosphorylation	CSPAQSLSSGSGSGG CCCCHHCCCCCCCCC	37.59	-
375	Phosphorylation	GRLFAPPSPETGEAK CEEECCCCCCCCCCH	34.02	28450419
378	Phosphorylation	FAPPSPETGEAKRSA ECCCCCCCCCCHHHH	43.64	22199227
447	Phosphorylation	RPGGPLPSRLEGGSP CCCCCCCCCCCCCCC	58.12	30631047
507	Phosphorylation	AFSQPARSFSQLSPL HHCCCCCCHHHCCHH	31.21	27732954
509	Phosphorylation	SQPARSFSQLSPLVL CCCCCCHHHCCHHHH	31.30	27732954
512	Phosphorylation	ARSFSQLSPLVLGQK CCCHHHCCHHHHCCC	14.46	27732954
652	Phosphorylation	RSHHKKEYAMEPLVK HHHCCHHHHCHHHHH	21.81	25954137

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PRDM8_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PRDM8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PRDM8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NHLC1_HUMAN	NHLRC1	physical	22961547

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.